Pharma Flashcards
On which channel does succinylcholine work?
Sodium channel
What is the depolarizing agent no longer used called?
Decamethonium
How to choose between topical and systemic route for a skin disease?
Start with topical and move to systemic if disease doesn’t respond
How to choose between oil-based and water-based vehicle for a topical treatment?
Water for acute, wet,thin
Oil for chronic,dry,thick
What’s the difference between 1st and 3rd generation retinoids?
3rd generation doesn’t decrease sebum production
What are the side effects common between topical drugs?
Peeling, dryness and irritation
What is the most common oral acne antibiotic?
Minocycline
What is the non-protein inhibitor antibiotic used topically for acne?
Dapsone
What are the 3rd generation retinoids called and what are they used for?
Adapalene & Tazarotene ; 1st choice for comedonal and inflammatory acne
Name the prophylaxis antibiotics used on skin injuries
Bacitracin (+) & Polymyxin B (-)
Name the antibiotics used to treat skin infections
Mupirocin (+)
(Neo/Genta)mycin (-)
What is Neosporin made of ?
Bacitracin + Polymyxin B + Neomycin
What can we use for seborrheic dermatitis ?
Ciclopirox
1% shampoo for scalp
0.77% cream for face
When are should acyclovir and pencyclovir best given?
Right before the onset of symptoms (eg. numbness)
What causes pediculosis?
Lice
Tachyphylaxis is a side effect of what topical drug?
Topical corticosteroids
Name the antihistamine used for pruritis
Doxepin
What can we use for severe pruritus?
Topical anesthesia (Pramoxin)
What system does rheumatoid arthritis not affect?
CNS
How fast should remission happen after diagnosis?
2 months
Should rheumatoid arthritis patients exercise?
Yes but not during rheumatic crisis
What time of the day should rheumatoid arthritis be given?
Morning
What are the indications of corticosteroids used in rheumatoid arthritis?
1) bridging therapy
2) Severe arthritis even with DMARDs
How can you protect the stomach from corticosteroids in rheumatoid treatment?
Give PPI (EXCEPT H2 BLOCKERS)
Rheumatoid arthritis patient treated with Corticosteroids has joint swelling what could this be?
Treatment failure (many joints)
Infection (one joint)
What route of corticosteroids do we use for rheumatoid arthritis?
Oral, IV for severe and if it doesn’t work then IM
What are the first NSAID, Corticosteroids and DMARDs you should try for RA?
Ibuprofen ; Prednisolone ; MTX
How long does it take MTX to work?
6 months
When is NSAID used for RA?
Starting monotherapy before confirming the diagnosis
In what DMARDs should vaccine be given before treatment?
Rituximab & abatacept
How long does it take for Methotrexate to start working?
6 months
What DMARDs to use if MTX causes lung fibrosis ?
Leflunomide or azathioprine
What to use for pregnant patient with RA?
Azathioprine
Sulfasalazine
TNF-a inhibitors
Hydroxychloroquine
What DMARDs to use for mild cases?
Hydroxychloroquine & Minocycline (antibiotics)
What DMARDs should only be used in combination therapy and why?
Infliximab; prevent Ab development & allergic reaction
Which jak inhibitor is not a DMARD?
Tofacitinib
What mnemonic can be used for memorizing Biological DMARDs?
TNF-a ; sister.lizzie intercepts In Adil’s Goals
Non-TNF-a; Talk-to-lizzie (in) Ankara about-accepting Rital (Adil’s wife)
