Pharma Flashcards

1
Q

On which channel does succinylcholine work?

A

Sodium channel

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2
Q

What is the depolarizing agent no longer used called?

A

Decamethonium

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3
Q

How to choose between topical and systemic route for a skin disease?

A

Start with topical and move to systemic if disease doesn’t respond

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4
Q

How to choose between oil-based and water-based vehicle for a topical treatment?

A

Water for acute, wet,thin
Oil for chronic,dry,thick

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5
Q

What’s the difference between 1st and 3rd generation retinoids?

A

3rd generation doesn’t decrease sebum production

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6
Q

What are the side effects common between topical drugs?

A

Peeling, dryness and irritation

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7
Q

What is the most common oral acne antibiotic?

A

Minocycline

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8
Q

What is the non-protein inhibitor antibiotic used topically for acne?

A

Dapsone

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9
Q

What are the 3rd generation retinoids called and what are they used for?

A

Adapalene & Tazarotene ; 1st choice for comedonal and inflammatory acne

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10
Q

Name the prophylaxis antibiotics used on skin injuries

A

Bacitracin (+) & Polymyxin B (-)

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11
Q

Name the antibiotics used to treat skin infections

A

Mupirocin (+)
(Neo/Genta)mycin (-)

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12
Q

What is Neosporin made of ?

A

Bacitracin + Polymyxin B + Neomycin

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13
Q

What can we use for seborrheic dermatitis ?

A

Ciclopirox
1% shampoo for scalp
0.77% cream for face

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14
Q

When are should acyclovir and pencyclovir best given?

A

Right before the onset of symptoms (eg. numbness)

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15
Q

What causes pediculosis?

A

Lice

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16
Q

Tachyphylaxis is a side effect of what topical drug?

A

Topical corticosteroids

17
Q

Name the antihistamine used for pruritis

A

Doxepin

18
Q

What can we use for severe pruritus?

A

Topical anesthesia (Pramoxin)

19
Q

What system does rheumatoid arthritis not affect?

A

CNS

20
Q

How fast should remission happen after diagnosis?

A

2 months

21
Q

Should rheumatoid arthritis patients exercise?

A

Yes but not during rheumatic crisis

22
Q

What time of the day should rheumatoid arthritis be given?

A

Morning

23
Q

What are the indications of corticosteroids used in rheumatoid arthritis?

A

1) bridging therapy
2) Severe arthritis even with DMARDs

24
Q

How can you protect the stomach from corticosteroids in rheumatoid treatment?

A

Give PPI (EXCEPT H2 BLOCKERS)

25
Q

Rheumatoid arthritis patient treated with Corticosteroids has joint swelling what could this be?

A

Treatment failure (many joints)
Infection (one joint)

26
Q

What route of corticosteroids do we use for rheumatoid arthritis?

A

Oral, IV for severe and if it doesn’t work then IM

27
Q

What are the first NSAID, Corticosteroids and DMARDs you should try for RA?

A

Ibuprofen ; Prednisolone ; MTX

28
Q

How long does it take MTX to work?

A

6 months

29
Q

When is NSAID used for RA?

A

Starting monotherapy before confirming the diagnosis

30
Q

In what DMARDs should vaccine be given before treatment?

A

Rituximab & abatacept

31
Q

How long does it take for Methotrexate to start working?

A

6 months

32
Q

What DMARDs to use if MTX causes lung fibrosis ?

A

Leflunomide or azathioprine

33
Q

What to use for pregnant patient with RA?

A

Azathioprine
Sulfasalazine
TNF-a inhibitors
Hydroxychloroquine

34
Q

What DMARDs to use for mild cases?

A

Hydroxychloroquine & Minocycline (antibiotics)

35
Q

What DMARDs should only be used in combination therapy and why?

A

Infliximab; prevent Ab development & allergic reaction

36
Q

Which jak inhibitor is not a DMARD?

A

Tofacitinib

37
Q

What mnemonic can be used for memorizing Biological DMARDs?

A

TNF-a ; sister.lizzie intercepts In Adil’s Goals
Non-TNF-a; Talk-to-lizzie (in) Ankara about-accepting Rital (Adil’s wife)