pharma

Question 1

antagonist

Answer 1

prevents something

Question 2

agonist

Answer 2

initiates something

Question 3

competitive antagonist

Answer 3

bind to the same receptor as agonist but do not activate it

Question 4

non competitive agonist

Answer 4

binds to allosteric site to prevent it

Question 5

irreversible antagonist

Answer 5

covalently bonded and cannot be removed

Question 6

inhibitor

Answer 6

binds to a protein to decrease its activity

Question 7

overcome reversible agonist

Answer 7

administer more agonist

Question 8

reaching steady state concentration for oral drug

Answer 8

3-5x half life

Question 9

partial agonist

Answer 9

lower efficacy and cannot produce maximal response

Question 10

EH

Answer 10

proportion of the drug that is cleared by the liver

Question 11

fH

Answer 11

proportion of the drug that is absorbed from GI that actually enters systemic circulation

Question 12

rate of absorption factors

Answer 12

lipophilicity, charged, size, gastric emptying

Question 13

bioavailability equation

Answer 13

F= fg x fH

fg is proportion absorbed from the gut

Question 14

unbound drugs

Answer 14

only unbound can distribute

Question 15

volume of distribution

Answer 15

fluid that would be required to distribute the full dose of a drug at the concentration it is observed in the blood

Question 16

determinants of half life

Answer 16

proportional to volume of distribution

inversely proportional to systemic clearance

Question 17

functionalisation reaction

Answer 17

Cytochrome P450

Question 18

conjugation reaction

Answer 18

UGT

Question 19

renal elimination

Answer 19

filtration in the glomerulus, only unbound drugs

Question 20

clearance

Answer 20

volume of blood cleared irreversibly of a drug

Question 21

low hepatic clearance

Answer 21

less than 300mL

Question 22

high hepatic clearance

Answer 22

over 1000mL