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Block test > pharma > Flashcards

pharma Flashcards

1
Q

antagonist

A

prevents something

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2
Q

agonist

A

initiates something

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3
Q

competitive antagonist

A

bind to the same receptor as agonist but do not activate it

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4
Q

non competitive agonist

A

binds to allosteric site to prevent it

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5
Q

irreversible antagonist

A

covalently bonded and cannot be removed

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6
Q

inhibitor

A

binds to a protein to decrease its activity

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7
Q

overcome reversible agonist

A

administer more agonist

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8
Q

reaching steady state concentration for oral drug

A

3-5x half life

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9
Q

partial agonist

A

lower efficacy and cannot produce maximal response

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10
Q

EH

A

proportion of the drug that is cleared by the liver

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11
Q

fH

A

proportion of the drug that is absorbed from GI that actually enters systemic circulation

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12
Q

rate of absorption factors

A

lipophilicity, charged, size, gastric emptying

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13
Q

bioavailability equation

A

F= fg x fH

fg is proportion absorbed from the gut

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14
Q

unbound drugs

A

only unbound can distribute

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15
Q

volume of distribution

A

fluid that would be required to distribute the full dose of a drug at the concentration it is observed in the blood

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16
Q

determinants of half life

A

proportional to volume of distribution

inversely proportional to systemic clearance

17
Q

functionalisation reaction

A

Cytochrome P450

18
Q

conjugation reaction

A

UGT

19
Q

renal elimination

A

filtration in the glomerulus, only unbound drugs

20
Q

clearance

A

volume of blood cleared irreversibly of a drug

21
Q

low hepatic clearance

A

less than 300mL

22
Q

high hepatic clearance

A

over 1000mL

Block test (7 decks)

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