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FA - Pharmacology > Pharm - Toxicities and Side Effects (Drug Reactions Part 2: Musculo, Neuro, Renal/GU, Resp, & Multiorgan) > Flashcards

Pharm - Toxicities and Side Effects (Drug Reactions Part 2: Musculo, Neuro, Renal/GU, Resp, & Multiorgan) Flashcards

Pg. 254-255 in First Aid 2014 Sections include: -Drug reactions-musculoskeletal/skin/connective tissue -Drug reactions-neurologic -Drug reactions-renal/genitourinary -Drug reactions-respiratory -Drug reactions-multiorgan

1
Q

What are 10 potential musculoskeletal/connective tissue drug reactions?

A

(1) Fat redistribution (2) Gingival hyperplasia (3) Hyperuricemia (gout) (4) Myopathy (5) Osteoporosis (6) Photosensitivity (7) Rash (Stevens-Johnson syndrome) (8) SLE-like syndrome (9) Teeth discoloration (10) Tendonitis, tendon rupture, and cartilage damage

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2
Q

What 2 drug cause Fat redistribution?

A

(1) Glucocorticoids, (2) Protease inhibitors; Think: “Fat PiG”

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3
Q

What 4 drug cause Gingival hyperplasia?

A

(1) Phenytoin, (2) Verapamil, (3) Cyclosporine, (4) Nifedipine

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4
Q

What 5 drugs cause Hyperuricemia (gout)?

A

(1) Pyrazinamide, (2) Thiazides, (3) Furosemide, (4) Niacin, & (5) Cyclosporine; Think: “Painful Tophi and Feet Need Care”

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5
Q

What 8 drugs cause Myopathy?

A

(1) Fibrates, (2) Niacin, (3) Colchicine, (4) Hydroxychloroquine, (5) Interferon-alpha, (6) Penicillamine, (7) Statins, (8) Glucocorticoids

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6
Q

What 2 drugs cause Osteoporosis?

A

(1) Corticosteroids, (2) Heparin

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7
Q

What 4 drugs cause Photosensitivity?

A

(1) Sulfonamides, (2) Amiodarone, (3) Tetracycline, (4) 5-FU; Think: “SAT For a Photo”

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8
Q

What 4 kinds of drugs cause Rash (Stevens-Johnson syndrome)?

A

(1) Anti-epileptic drugs (Ethosuximide, Carbamazapine, Lamotrigine, Phenytoin, Phenobarbital) (2) Allopurinol (3) Sulfa drugs (4) Penicillin; Think: “Steven Johnson has Epileptic ALLergy to Sulfa drugs and Penicillin.”

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9
Q

What 6 drugs cause SLE-like syndrome?

A

(1) Sulfa drugs, (2) Hydralazine, (3) Isoniazid (INH), (4) Procainamide, (5) Phenytoin, (6) Etanercept; Think: “having lupus is ‘SHIPP-E’”

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10
Q

What drug causes Teeth discoloration?

A

Tetracyclines

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11
Q

What drugs cause Tendonitis, tendon rupture, and cartilage damage?

A

Fluoroquinolones

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12
Q

What one reaction do all of the following drugs cause: glucocorticosteroids, protease inhibitors?

A

Fat redistribution

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13
Q

What one reaction do all of the following drugs cause: Phenytoin, verapamil, cyclosporine, nifedipine?

A

Gingival hyperplasia

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14
Q

What one reaction do all of the following drugs cause: Pyrazinamide, Niacin, Cyclosporine, Furosemide, Thiazide?

A

Hyperuricemia (Gout)

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15
Q

What one reaction do all of the following drugs cause: Fibrates, Niacine, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids?

A

Myopathy

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16
Q

What one reaction do all of the following drugs cause: Corticosteroids, heparin?

A

Osteoporosis

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17
Q

What one reaction do all of the following drugs cause: Sulfonamides, Amiodarone, Tetracycline, 5-FU?

A

Photosensitivity

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18
Q

What one reaction do all of the following drugs cause: Anti-epileptic drugs (Ethosuximide, Carbamazepine, Lamotrigine, Phenobarbital, Phenytoin), Allopurinol, Sulfa drugs, Penicillin?

A

Rash (Stevens-Johnson Syndrome)

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19
Q

What one reaction do all of the following drugs cause: Sulfa drugs, Hydralazine, Isoniazid (INH), Procainamide, Phenytoin, Etanercept?

A

SLE-like syndrome

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20
Q

What musculoskeletal/connective tissue reaction does tetracycline alone cause?

A

Teeth discoloration

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21
Q

What musculoskeletal/connective tissue reaction do fluoroquinolones alone cause?

A

Tendonitis, tendon rupture, and cartilage damage

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22
Q

What are 4 potential neurologic drug reactions?

A

(1) Cinchonism (2) Parkinson-like syndrome (3) Seizures (4) Tardive dyskinesia

23
Q

What are 2 drugs that cause Cinchonism?

A

(1) Quinidine (2) Quinine

24
Q

What are 3 drugs that cause Parkinson-like syndrome?

A

(1) Antipsychotics (2) Reserpine (3) Metoclopramide; Think: “cogwheel rigidity of ARM”

25
Q

What are 6 drugs that cause Seizures?

A

(1) INH (vitamin B6 deficiency) (2) Bupropion (3) Imipenem/Cilastatin (4) Tramadol (5) Enflurane (6) Metoclopramide; Think: “with SEIZURES, I BITE My tongue”

26
Q

What are 2 drugs that cause Tardive dyskinesia?

A

(1) Antipsychotics (2) Metoclopramide

27
Q

What drug reaction do all of the following drugs cause: Quinidine, Quinine?

A

Cinchonism

28
Q

What drug reaction do all of the following drugs cause: Antipsychotics, Reserpine, Metoclopramide?

A

Parkinson-like syndrome

29
Q

What drug reaction do all of the following drugs cause: INH, Bupropion, Imipenem/Cilastatin, Tramadol, Enflurane, Metoclopramide?

A

Seizures

30
Q

What drug reaction do all of the following drugs cause: Antipsychotics, Metoclopramide?

A

Tardive dyskinesia

31
Q

What are 5 potential renal/genitourinary drug reactions?

A

(1) Diabetes insipidus (2) Fanconi syndrome (3) Hemorrhagic cystitis (4) Interstitial nephritis (5) SIADH

32
Q

What 2 drugs cause Diabetes insipidus?

A

(1) Lithium (2) Demeclocycline

33
Q

What drug causes Fanconi syndrome?

A

Expired tetracycline

34
Q

What 2 drugs cause Hemorrhagic cystitis? How is this prevented?

A

(1) Cyclophosphamide, (2) Ifosfamide; Prevent by coadministering with mesna

35
Q

What 3 drugs cause Interstitial nephritis?

A

(1) Methicillin (2) NSAIDs (3) Furosemide

36
Q

What 3 drugs cause SIADH?

A

(1) Carbamazepine (2) Cyclophosphamide (3) SSRIs; Think: “Can’t Concentrate Serum Sodium”

37
Q

What drug reaction do all of the following drugs cause: Lithium, demeclocycline?

A

Diabetes insipidus

38
Q

What drug reaction does expired tetracycline cause?

A

Fanconi syndrome

39
Q

What drug reaction do all of the following drugs cause: Cyclophosphamide, Ifosfamide? Again, how is this reaction prevented?

A

Hemorrhagic cystitis; Prevent by coadministering with mesna

40
Q

What drug reaction do all of the following drugs cause: Methicillin, NSAIDs, Furosemide?

A

Interstitial nephritis

41
Q

What drug reaction do all of the following drugs cause: Carbamazepine, Cyclophosphamide, SSRIs?

A

SIADH

42
Q

What are 2 potential respiratory drug reactions?

A

(1) Dry cough (2) Pulmonary fibrosis

43
Q

What drugs cause dry cough?

A

ACE inhibitors

44
Q

What 4 drugs cause Pulmonary fibrosis?

A

(1) Bleomycin (2) Amiodarone (3) Busulfan (4) Methotrexate; Think: “Breathing Air Badly from Medications”

45
Q

What respiratory drug reaction do ACE inhibitors alone cause?

A

Dry Cough

46
Q

What one reaction do all of the following drugs cause: Bleomycin, Amiodarone, Busulfan, Methotrexate?

A

Pulmonary fibrosis

47
Q

What are 3 potential multiorgan drug reactions?

A

(1) Antimuscarinic (2) Disulfiram-like reaction (3) Nephrotoxicity/Ototoxicity

48
Q

What are 4 drugs that cause Antimuscarinic reactions?

A

(1) Atropine (2) TCAs (3) H1-blockers (4) Antipsychotics

49
Q

What are 5 drugs that cause Disulfiram-like reaction?

A

(1) Metronidazole (2) Certain Cephalosporins (3) Griseofulvin (4) Procarbazine (5) 1st generation sulfonylureas

50
Q

What are 4 drugs that cause Nephrotoxicity/Ototoxicity?

A

(1) Aminoglycosides (2) Vancomycin (3) Loop diuretics (4) Cisplatin

51
Q

What one reaction do all of the following drugs cause: Atropine, TCAs, H1 blockers, Antipyschotics?

A

Antimuscarinic

52
Q

What one reaction do all of the following drugs cause: Metronidazole, Certain Cephalosporins, Griseofulvin, Procarbazine, 1st-generation sulfonylureas?

A

Disulfiram-like reaction

53
Q

What one reaction do all of the following drugs cause: Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin?

A

Nephrotoxicity/Ototoxicity

FA - Pharmacology (14 decks)

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