Pharm: Tobacco, Vaping, Medical MJ, CBD Flashcards

1
Q

Why are adolescents more vulnerable to using drugs/addiction?

A

incomplete prefrontal cortex development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How does nicotene affect adolescents?

A

interferes with the maturation (neuroplasticity is impaired) –>

  • long term cognitive impairment
  • decreased memory and attention
  • behavior disturbances later in life
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What vaping ingredient is theorized to be involved in lung damage?

A

vitamin E acetate

safe to ingest, not safe to inhale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the main cannabinoids?

A

THC

CBD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the MOA of MJ?

A

stimulates endocannabinoid receptors (CB1, CB2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is anadamide?

A

partial CB1R agonist

broken down by fatty acid amide hydrolysis (FAAH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is mediated by CB1Rs?

A

analgesia

appetite enhancement

muscle relaxation

hormonal actions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dronabinol is a ___.

A

synetheic THC

used for: anorexia in AIDS pts, chemotherapy induced N/V, obstructive sleep apnea

*nabilone - THC capsule used for chemo induced N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What substance can improve spasticity in MS pts?

A

cannabis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What conditions does cannabis lack efficacy?

A

acute pain

HD

tremor in MS

glaucoma

schizophrenia

depression

slowing cancer growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CIs of Cannabis

A

hx of psychosis

current or past substance abuse disorder

CV or respiratory disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What would be the theoretical benefit of a FAAH inhibitor?

A

less breakdown of endocannabinoids anandamide –> less pain, axiety, fear…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How CBD is generally adminstered?

A

orally

metabolized via CYP3A4 and CYP2C19

rapidly distrubutes, and accumulates in adipose tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

At what receptors is CBD an agonist?

A

CB1

CB2

TRPV1

PPARy

5-HT1A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the benefits of CBD tx?

A

no CV effects

no psychoactive effects

no potential for abuse

no tolerance/withdrawal

no effect on embryo development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When is CBD a usefule tx?

A

Epilepsy (Dravet Syndrome, Lennox-Gastaut Syndrome)

AD

Fragile X Syndrome

skin diseases, cancer, menstraul pain, anxiety, pain