Pharm: ADHD Flashcards
What is the MOA of the stimulants used for ADHD?
- Block presynaptic reuptake, interference with VMAT
- ↑ in NT release —> NE, then DA, then 5-HT each at ↑ dose
Which isomers of AMP/MPH have more CNS activity?
D-isomers of AMP/MPH
What is methylphenidate’s main activity (MOA)?
- Inhibition of DA reuptake and inhibition of NT pre-synaptic reuptake
- Doesn’t appear to stimulate release of NT’s
What must you always assess for before prescribing stimulants for ADHD?
Structural cardiac abnormalities
What is the onset of activity for stimulants in most patients?
Usually 24 hours
What is the duration of action of the IR amphetamine-based stimulants?
4-6 hours
Which IR amphetamine-based stimulant comes in a liquid form?
Dextroamphetamine Sulfate / ProCentra
Which IR amphetamine-based stimulant comes in a capsule form?
Amphetamine Sulfate/ Evekeo
Which XR amphetamine-based stimulant comes in a liquid form with a 13-hour duration of action?
Amphetamine / Dyanavel XR
Which XR amphetamine-based stimulant comes in a capuslar form and has the longest duration (16 hrs)?
Amphetamine (mixed salts) / Mydayis
What is Adzenys XR-ODT used for ADHD and who is it given to?
- Non-IR form of amphetamine –> 50% IR and 50% XR
- 3:1 ratio of d-amphetamine and L-amphetamine
- NO water necessary –> children 6 y/o +
Which 2 IR methylphenidate-based stimulants used for ADHD come in a tab form; what is the their duration of action?
- Dexmethylphenidate / Focalin: 4-6 hours
- Methylphenidate / Ritalin: 3-4 hours
Which IR methylphenidate-based stimulants comes in a liquid form and has a 3-4 hour duration of action?
Methylphenidate / Methylin Oral solution
What are the 2 sustained-release methylphenidate-based stimulants?
- Methylphenidate / Ritalin-SR
- Methamphetamine / Desoxyn
Which XR methylphenidate-based stimulant comes as a transdermal patch?
Methylphenidate Transdermal / Daytrana