Pharm Test 5 Drugs- Cholinergic Antagonists

Question 1

Atropine

Answer 1

antimuscularinic

• belladonna alkaloid
• Cardiac dose dependent (low dose lowers HR)
• eye dilation, dry mouth, less sweat, increase HR, help with heart impulses
• enters CNS

Question 2

Scopolamine

Answer 2

antimuscularinic

• similar to atropine, but longer duration
• motion sickness, ear patches
• enters CNS

Question 3

Iptratropium

Answer 3

(Atrovent) antimuscularinic

• positive charge derivative of atropine, but no CNS
• inhaled, helps with COPD, bronchodilation

Question 4

Benztropine

Answer 4

(Cogentin) antimuscularinic

• treats Parkinson’s tremors (para has taken over), so we want to decrease para
• enters CNS

Question 5

Glycopyrrolate

Answer 5

(Robinul) antimuscularinic

• peptic ulcers
• decrease saaliva, give to stomach before surgery

Question 6

Nicotine

Answer 6

ganglionic blocker

• low dose stimulates nicotinic receptors
• high dose blocks them- and so brain makes more neurotransmitters= feels good
• enters CNS
• no effect at NMJ

Question 7

Vercuronium

Answer 7

non depolarizing neuromuscular blocker

-44 min duration- shorter time to recover

Question 8

Cisatracurium

Answer 8

(Nimbex) non depolarizing neuromuscular blocker

-90 min duration- longer time to recover

Question 9

Pancuronium

Answer 9

(Pavulon) non depolarizing neuromuscular blocker

-90 min duration

Question 10

Rocuronium

Answer 10

(Zemuron) non depolarizing neuromuscular blocker

-44 min duration

Question 11

Sugammadex

Answer 11

(Bridion) non depolarizing neuromuscular blocker REVERSAL

- surrounds blockers and inactivates

Question 12

Succinylcholine

Answer 12

(Anectine, SUX) depolarizing neuromuscular blocker

• prevents vomit during surgery, endotracheal intubation
• side effects- hyperthermia, hyperkalemia, apnea