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pharm side effect Flashcards

1
Q

antidote for Amphetamines OD

A

amphetamines are basic so acidify urine (NH4Cl)

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2
Q

antidote for beta blocker OD

A

glucagon

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3
Q

antidote for digitalis OD

A

Anti-dig Fab fragments

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4
Q

antidote for Mercury, arsenic, gold OD

A

Dimercaprol (BAL), succimer

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5
Q

antidote for lead OD

A

EDTA, dimercaprol, succimer, penicillamine

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6
Q

antidote for salicylates OD

A

NaHCO3 (alkalinize urine), dialysis

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7
Q

antidote for TCAs OD

A

NaHCO3 (plasma alkalinization)

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8
Q

antidote for tPA, streptokinase, urokinase

A

aminocaproic acid

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9
Q

drugs that cause cutaneous flushing

A

VANC: vanc, adenosine, niacin, CCB

Flushing:
tamoxifen
amlodipine
nicorandil
isosorbide mononitrate
sildenafil
niacin
diltiazem
verapamil
hydralazine
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10
Q

drugs that cause hot flashes

A

tamoxifen, clomiphene

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11
Q

drugs that cause hyperglycemia

A

tacrolimus, protease inhibitors, niacin, HCTZ, beta blockers, corticosteroids

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12
Q

drugs that cause pancreatitis

A

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

propofal

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13
Q

drugs that cause agranulocytosis

A

dapsone, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil

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14
Q

drugs that cause aplastic anemia

A

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil

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15
Q

drugs that cause megaloblastic anemia

A

phenytoin, methotrexate, SULFA drugs, TMP,
decrease in Folate, B12
cytaribine

SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas,

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16
Q

drugs that cause gingival hyperplasia

A

phenytoin,
verapamil, nifedipine,
cyclosporine, tracrolimus - these two also cause hirustism.

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17
Q

drugs that cause photosensitivity

A

sulfonamides, amiodarone , tetracycline, 5-FU

SAT for a Foto

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18
Q

SLE like syndromes

A

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept, methyl-dopa

SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas,

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19
Q

drugs that causes seizures

A

INH, Bupropion, Imipenem/Cilastatin, Tramadol, Enflurane, Metoclopramide

antipsychotics- atypicals
foscarnet
ciprofloxacin

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20
Q

drugs that causes diabetes insipidus

A

lithium, demeclocycline

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21
Q

drugs that cause interstitial nephritis

A

methicillin (pencillins), NSAIDs, furosemide, sunfomanides, rifampin

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22
Q

drugs that cause SIADH

A

carbamazepine, cyclophosphamide, SSRIs, LI

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23
Q

drugs that cause nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

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24
Q

DCM

A

doxirubicin, daunorubicin. give dexrazoxane

25
Torsades
``` Class III (sotalol) Class IA(quinidine) macrolides - erythro, azithro, clarithro antipsychotics - atypical: ziprasidone TCAs ```
26
hypothyrodism
Li, amiodrone, sulfonamides
27
gyncomastia
spironolactone, digitalis, cimetidine, chronic EToH, estrogens, ketaconazole, cannibus
28
acute cholestatic heptitis, jaundice
erythromycin
29
diarrhea
metformin, erythro, colchicine, orlistat, acrobose
30
focal to massive necrosis of liver
haltANE, amanita phallodies valproic acid apap
31
heptitis hepatotoxic
isoniazid, halothane ``` pioglitazone halothane valproic acid rifampin amiodarone sulfonylureas ciclosporin methotrexate phenytoin pyrazinamide statins sodium valproate ```
32
pseduomembranous colitis
clinda, ampicillin, cephalosprines
33
thrombocytopenia
heparin (HIT), cimetidine (H2 blocker) ``` heparin valproic acid quinidine sodium valproate thiazides ```
34
G6PD def
INH, sulfonamides, dapsone, primiquine, aspirin, ibuprofen, nitrofurantoin, aspirin, flava beans, napthalene.
35
SJS
``` ethosuxamide carbamazepine lamotrigine phenytoin phenobarbital allopurinol pencillins SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas, ```
36
cinchonism
quinidine, quinine cinchonism- headache, tinnitus, thrombocytopenia
37
fanconi syndrome
expired tetracyclines
38
types of CCB and used? | Se?
verapmil, diltiazem = non-dihydropyridine = carido selective. for angina, Afib/flutter Nifedipine, amlidipine, nimodipine = dyhydropyridines= peripheral vascualr smooth M. raynauds, Prinzmetal angina. nimodipine= vasospasm in subarachnoid hemorrhage Se: constiplation. AV block. peripheal edema, flushing, diszziness, hyperProlactinemia Verpapmil + nifedpine - gingival hyerplasia
39
alemtuzumab
CD52 CLL
40
bevacizumab
VEGF CRC RCC
41
cetuximab
EGFR (proto-oncogene) CRC lung adenocarcinoma
42
rituximab
CG20 RA, B cell non-hodgkins lymphoma
43
Transtuzumab
HER2/Nu/ ERB-b2 breast and gastric cancer
44
inflixmab adalimumab etancept
TNF A etancept is not an Ab but the traget is TNF A
45
Natalizumab
alpha 4 integrins used for leukocyte adhesion. Risk of PML with JC virus MS crohns
46
abciximab
GP IIb/IIIa anti-platelet agent used for pts going PCI
47
denosumab
RANK L- | inhibit OC
48
omalizumab
IgE for allergic asthma. prevents IgE from binding FceRI
49
Palivizumab
RSV F Protein | RSV ptx in infants
50
muronomab
CD3 to decrease T cell signal tranduction before Renal Transplant
51
Daclizumab
CD25/ (IL 2 R) T cell receptor
52
oprelvekin
IL 11. used for thrombocytopenia
53
sargramostim
GM- CSF used to recover BM
54
aldeesleukin
IL 2 used for RCC and metastatic melanoma
55
hypotention
``` verapamil loop diuretics isosorbide mononitrate diltiazem atracurium levodopa bromocriptine ACE inhibitors thiazides amlodipine ```
56
Deep inguinal lymph nodes
glans penis
57
Precipitation of digoxin toxicity
``` Precipitation of digoxin toxicity amiodarone ciclosporin loop diuretics thiazides diltiazem verapamil quinidine spironolactone beta-blockers digoxin ```
58
causes of renal palillary necrosis
``` long term aspirin use penoacetin (its in acetaminophen) DM Sickle cell dz or trait acute pylonephritis ```

step 1 flashcards (13 decks)

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