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step 1 flashcards > pharm side effect > Flashcards

pharm side effect Flashcards

1
Q

antidote for Amphetamines OD

A

amphetamines are basic so acidify urine (NH4Cl)

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2
Q

antidote for beta blocker OD

A

glucagon

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3
Q

antidote for digitalis OD

A

Anti-dig Fab fragments

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4
Q

antidote for Mercury, arsenic, gold OD

A

Dimercaprol (BAL), succimer

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5
Q

antidote for lead OD

A

EDTA, dimercaprol, succimer, penicillamine

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6
Q

antidote for salicylates OD

A

NaHCO3 (alkalinize urine), dialysis

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7
Q

antidote for TCAs OD

A

NaHCO3 (plasma alkalinization)

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8
Q

antidote for tPA, streptokinase, urokinase

A

aminocaproic acid

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9
Q

drugs that cause cutaneous flushing

A

VANC: vanc, adenosine, niacin, CCB

Flushing:
tamoxifen
amlodipine
nicorandil
isosorbide mononitrate
sildenafil
niacin
diltiazem
verapamil
hydralazine
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10
Q

drugs that cause hot flashes

A

tamoxifen, clomiphene

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11
Q

drugs that cause hyperglycemia

A

tacrolimus, protease inhibitors, niacin, HCTZ, beta blockers, corticosteroids

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12
Q

drugs that cause pancreatitis

A

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

propofal

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13
Q

drugs that cause agranulocytosis

A

dapsone, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil

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14
Q

drugs that cause aplastic anemia

A

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil

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15
Q

drugs that cause megaloblastic anemia

A

phenytoin, methotrexate, SULFA drugs, TMP,
decrease in Folate, B12
cytaribine

SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas,

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16
Q

drugs that cause gingival hyperplasia

A

phenytoin,
verapamil, nifedipine,
cyclosporine, tracrolimus - these two also cause hirustism.

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17
Q

drugs that cause photosensitivity

A

sulfonamides, amiodarone , tetracycline, 5-FU

SAT for a Foto

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18
Q

SLE like syndromes

A

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept, methyl-dopa

SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas,

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19
Q

drugs that causes seizures

A

INH, Bupropion, Imipenem/Cilastatin, Tramadol, Enflurane, Metoclopramide

antipsychotics- atypicals
foscarnet
ciprofloxacin

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20
Q

drugs that causes diabetes insipidus

A

lithium, demeclocycline

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21
Q

drugs that cause interstitial nephritis

A

methicillin (pencillins), NSAIDs, furosemide, sunfomanides, rifampin

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22
Q

drugs that cause SIADH

A

carbamazepine, cyclophosphamide, SSRIs, LI

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23
Q

drugs that cause nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

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24
Q

DCM

A

doxirubicin, daunorubicin. give dexrazoxane

25
Q

Torsades

A 
Class III (sotalol)
Class IA(quinidine)
macrolides - erythro, azithro, clarithro
antipsychotics - atypical: ziprasidone
TCAs
26
Q

hypothyrodism

A

Li, amiodrone, sulfonamides

27
Q

gyncomastia

A

spironolactone, digitalis, cimetidine, chronic EToH, estrogens, ketaconazole,
cannibus

28
Q

acute cholestatic heptitis, jaundice

A

erythromycin

29
Q

diarrhea

A

metformin, erythro, colchicine, orlistat, acrobose

30
Q

focal to massive necrosis of liver

A

haltANE,
amanita phallodies
valproic acid
apap

31
Q

heptitis

hepatotoxic

A

isoniazid, halothane

pioglitazone
halothane
valproic acid
rifampin
amiodarone
sulfonylureas
ciclosporin
methotrexate
phenytoin
pyrazinamide
statins
sodium valproate
32
Q

pseduomembranous colitis

A

clinda, ampicillin, cephalosprines

33
Q

thrombocytopenia

A

heparin (HIT), cimetidine (H2 blocker)

heparin
valproic acid
quinidine
sodium valproate
thiazides
34
Q

G6PD def

A

INH, sulfonamides, dapsone, primiquine, aspirin, ibuprofen, nitrofurantoin, aspirin, flava beans, napthalene.

35
Q

SJS

A 
ethosuxamide
carbamazepine
lamotrigine
phenytoin
phenobarbital
allopurinol
pencillins
SULFA drugs: aspirin, furosemide, acetoazolaminde, thiazides, celeoxib, probenecid, sulfinamides, sulfasalazine, sulfonylureas,
36
Q

cinchonism

A

quinidine,
quinine

cinchonism- headache, tinnitus, thrombocytopenia

37
Q

fanconi syndrome

A

expired tetracyclines

38
Q

types of CCB and used?

Se?

A

verapmil, diltiazem = non-dihydropyridine = carido selective. for angina, Afib/flutter

Nifedipine, amlidipine, nimodipine = dyhydropyridines= peripheral vascualr smooth M. raynauds, Prinzmetal angina.

nimodipine= vasospasm in subarachnoid hemorrhage

Se: constiplation. AV block. peripheal edema, flushing, diszziness, hyperProlactinemia

Verpapmil + nifedpine - gingival hyerplasia

39
Q

alemtuzumab

A

CD52

CLL

40
Q

bevacizumab

A

VEGF

CRC
RCC

41
Q

cetuximab

A

EGFR (proto-oncogene)

CRC
lung adenocarcinoma

42
Q

rituximab

A

CG20

RA, B cell non-hodgkins lymphoma

43
Q

Transtuzumab

A

HER2/Nu/ ERB-b2

breast and gastric cancer

44
Q

inflixmab
adalimumab

etancept

A

TNF A

etancept is not an Ab but the traget is TNF A

45
Q

Natalizumab

A

alpha 4 integrins used for leukocyte adhesion. Risk of PML with JC virus

MS
crohns

46
Q

abciximab

A

GP IIb/IIIa anti-platelet agent used for pts going PCI

47
Q

denosumab

A

RANK L-

inhibit OC

48
Q

omalizumab

A

IgE for allergic asthma. prevents IgE from binding FceRI

49
Q

Palivizumab

A

RSV F Protein

RSV ptx in infants

50
Q

muronomab

A

CD3 to decrease T cell signal tranduction before Renal Transplant

51
Q

Daclizumab

A

CD25/ (IL 2 R)

T cell receptor

52
Q

oprelvekin

A

IL 11. used for thrombocytopenia

53
Q

sargramostim

A

GM- CSF used to recover BM

54
Q

aldeesleukin

A

IL 2 used for RCC and metastatic melanoma

55
Q

hypotention

A 
verapamil
loop diuretics
isosorbide mononitrate
diltiazem
atracurium
levodopa
bromocriptine
ACE inhibitors
thiazides
amlodipine
56
Q

Deep inguinal lymph nodes

A

glans penis

57
Q

Precipitation of digoxin toxicity

A 
Precipitation of digoxin toxicity
amiodarone
ciclosporin
loop diuretics
thiazides
diltiazem
verapamil
quinidine
spironolactone
beta-blockers
digoxin
58
Q

causes of renal palillary necrosis

A 
long term aspirin use
penoacetin (its in acetaminophen)
DM
Sickle cell dz or trait
acute pylonephritis

step 1 flashcards (13 decks)

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