Pharm Rxns Flashcards
Coronary vasospasm can be caused by…
cocaine, sumatriptan and ergot alkaloids
Cutaneous flushing can be caused by…
vancomycin, adenosine, niacin, and calcium channel blockers
Dilated cardiomyopathy can be caused by…
doxorubicin and danorubicin
Torsades de pointes can be caused by
class III (sotalol) and class IA (quinidine) antiarrhythmics, macrolides, antipsychotics and TCAs
Adrenocortical insufficiency is caused by…
HPA suppression secondary to glucocorticoid withdrawal.
Hot flashes can be caused by…
tamoxifen and clomiphene.
Hyperglycemia can be caused by..
tacrolimus, protease inhibitors, niacin, HCTZ, beta-blockers and corticosteroids.
Hypothyroidism can be caused by…
lithium, amiodarone, and sulfonamides.
Acute cholestatic hepatitis and jaundice can be caused by…
erythromycin.
Diarrhea can be caused by…
Metformin, Erythromycin, Colchicine, Orlistat and Acarbose.
Focal to massive hepatic necrosis can be caused by…
halothane, amanita phalloides, valproic acid, and acetaminophen.
Pancreatitis can be caused by…
didanosine, corticosteroids, alcohol, valproic acid, azathioprine, and diuretics
Pseudomembranous colitis can be caused by…
clindamycin, ampicillin and cephalosporins
Agranulocytosis can be caused by…
dapsone, clozapine, carbamazepine, colchicine, methimazole, NSAIDs, and PTU
Aplastic anemia can be caused by…
carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol and PTU
Direct Coombs-positive hemolytic anemia can be caused by…
methyldopa and penicillin
Gray baby syndrome can be caused by…
chloramphenicol.
Hemolysis in G6PD deficiency can be caused by…
INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen and Nitrofurantoin.
Megaloblastic anemia can be caused by…
phenytoin, methotrexate and sulfa drugs.
Thrombocytopenia can be caused by…
heparin and cimetidine.
Fat redistribution is caused by…
protease inhibitors and glucocorticoids.
Gingival hyperplasia is caused by…
phenytoin, verapamil, cyclosporine and nifedipine.
Hyperuricemia (gout) can be caused by…
pyrazinamide, thiazides, furosemide, niacin and cyclosporine.
Myopathy can be caused by…
fibrates, niacin, cochicine, hydroxychloroquine, IFN-alpha, penicillamine, statins, and glucocorticoids.
Osteoporosis can be caused by..
corticosteroids and heparin.
Photosensitivity can be caused by…
sulfonamides, amiodarone, tetracyclines, and 5-FU.
Rash (Stevens-Johnson syndrome) is caused by…
Anti-epileptic drugs (ethosuxamide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, sulfa drugs and penicillin.
SLE-like syndrome is caused by…
sulfa drugs, hydralzine, INH, procainamide, phenytoin and etanercept.
Tendonitis, tendon rupture and cartilage damage is caused by…
fluoroquinolones.
Cinchonism is caused by…
quinidine and quinine.
Parkinson-like syndrome is caused by…
antipsychotics (esp. typicals), Reserpine and Metoclopramide.
Seizures are caused by…
INH (B6 deficiency), Bupropion, Imipenem/Cilastatin, Tramadol, Enflurane and Metoclopromide.
Tardive dyskinease is caused by…
Antipsychotics (esp. typicals) and Metoclopramide.
Diabetes insipidus can be caused by…
lithium and demeclocycline.
Fanconi syndrome can be caused by…
expired tetracylcine.
Hemorrhagic cystitis can be caused by…
cyclophosphamide and Ifosfamide. This side effect can be prevented by co-administering with Mesna.
Interstitial nephritis can be casued by…
methicillin, NSAIDs, and furosemide.
SIADH can be caused by…
carbamazepine, cyclophosphamide and SSRIs.
Dry cough can be caused by…
ACE inhibitors.
Pulmonary fibrosis can be caused by…
bleomycin, amiodarone, busulfan, and methotrexate.
Antimuscarinic rxns can be caused by…
atropine, TCAs, H1-blockers and antipsychotics.
Disulfiram-like reaction can be caused by…
metronidazole, cephalosporins, griseofulvin, procarbazine, and 1st gen sulfonylureas.
Nephrotoxicity/Ototoxicity can be caused by…
aminoglycosides, vancomycin, loop diuretics and cisplatin.
CYP450 Inducers (9)
- Chronic alcohol use 2. Modafinil 3. St. John’s wort 4. Phenytoin 5. Phenobarbital 6. Nevirapine 7. Rifampin 8. Griseofulvin 9. Carbamazepine (Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs)
CYP450s Substrates (8)
- Anti-epileptics 2. Antidepressants 3. Antipsychotics 4. Anesthetics 5. Theophylline 6. Warfarin 7. Statins 8. OCPs (Always, Always, Always, Always Think When Starting Others)
CYP450 Inhibitors (12)
- Acute alcohol abuse 2. Gemfibrozil 3. Ciprofloxacin 4. Isoniazid 5. Grapefruit juice 6. Quinidine 7. Amiodarone 8. Ketoconazole 9. Macrolides 10. Sulfonamides 11. Cimetidine 12. Ritonavir (A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls)
Sulfa drugs (8)
- Probenecid 2. Furosemide 3. Acetazolamide 4. Celecoxib 5. Thiazides 6. Sulfonamide antibiotics 7. Sulfasalazine 8. Sulfonylureas (Popular FACTSSS)
Pts who take sulfa drugs who have sulfa allergies may develop…
fever, UTIs, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis and urticaria.
