Pharm Questions

Question 1

SE: rash, Stevens-Johnson Syndrome, hypersensitivity syndrome, bone marrow suppression

Answer 1

Allopurinol

Question 2

Dx-dx: increase opioids, benzos, hypotensives, increases toxicity of ethanol, CNS depressant, TCAs, CLINDAMYCIN

Answer 2

Baclofen

Question 3

SE anticholinergic effects, inhibits SSRI, xerostomia, dizziness

Answer 3

cyclobenzaprine

Question 4

Black Box warning: TB, malignancy, infection

Answer 4

Tofacitinib (xeljanx)

Question 5

SE: 
arachnoiditis
subacute toxicity rxn (motor paralysis, CN palsey, seizure, coma)
pulmonary fiborsis
hepatotoxicity
bone marrow suppression
Stevens-Johnson syndrome

Answer 5

Methotrexate

Question 6

Indications:

1. RA
2. ulcerative colitis
3. off-label Crohns Disease
4. psoriasis
5. psoriatic arthritis

Answer 6

Sulfasalazine

Question 7

MOA: inhibition of cytokines and inflammatory mediators

Answer 7

prednisone

Question 8

MOA: Inhibits leukocyte migration, phagocytic activity

Answer 8

colchine

Question 9

Anticholingeric SE (urinary retention, tachycardia, hypotension)

sedation

Answer 9

amitryptiline

Question 10

Contra:

1. severe hepatic impairment (Child-Pugh score over 10)
2. severe asthma
3. closed glaucoma
4. CV disease
5. biliary tract disease
6. COPD

Answer 10

Pilocarpine

Question 11

Dx-Dx:

1. MAOIs
2. sedating drugs
3. SSRIs

Answer 11

tramadol

Question 12

rash with first infusion

Answer 12

Rituximab

Question 13

naturally occuring agonist of IL-1 receptor which reduces degradation of cartilage

Answer 13

Anakinra

Question 14

dx-dx:

1. anti-coags
2. NSAIDs
3. diuretics
4. lithium
5. anti-HTN meds

Answer 14

ibuprofen

Question 15

Indications:
1. RA
2. leukemias
3. breast cancer
4. lymphomas
5. myeloma
6/ corticoid refractory nephrotic syndrome

Answer 15

Cyclophosphamide

Question 16

reversible infertility in men

Answer 16

sulfasalazine

Question 17

counteracted by low dose ASA

Answer 17

probenacid

Question 18

possible rash with ampicillin/amoxicillin

Answer 18

allopurinol