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MSK > Misc. Pharm > Flashcards

Misc. Pharm Flashcards

1
Q

Cyclobenzaprine Class

A

Centrally-acting muscle relaxant

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2
Q

Cyclobenzaprine MOA

A

related to TCAs

reduces tonic somatic motor activity

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3
Q

Cyclobenzaprine Indication

A

muscle spasm

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4
Q

Cyclobenzaprine SE

A
  1. antichol effect
  2. CNS depression
  3. decreased serotonin reuptake
  4. xerostomia
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5
Q

Cyclobenzaprine Contra

A

1.

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6
Q

Cyclobenzaprine dx-dx

A
  1. increase anti-chol
  2. ethanol
  3. SSRI
  4. Tramadol
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7
Q

Cyclobenzaprine Monitor

A
  1. mental
  2. serotonin syndrome
  3. LFTs
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8
Q

Baclofen Class

A

Centrally-acting muscle relaxant

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9
Q

Baclofen MOA

A

Inhibits transmission of synaptic reflexes @SC level

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10
Q

Baclofen Indication

A
  1. MS

2. spinal cord lesions

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11
Q

Baclofen SE

A
  1. vertigo
  2. psych dist.
  3. slurred speech
  4. ataxia
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12
Q

Baclofen dx-dx

A
  1. increased opioids, benzos, htn-agents
  2. increase ethanol, CNS depressants, TCAs
  3. clindamycin
  4. MAOIs
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13
Q

Baclofen Other

A

Avoid with St. Johns wort, valerian, Kava kava

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14
Q

Dantrolene Class

A

Peripherally-acting muscle relaxant

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15
Q

Dantrolene MOA

A

acts directly on skeletal muscle, inhibits Ca release

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16
Q

Dantrolene Indications

A
  1. muscle spasticity due to CVA, CP, SC
  2. malignant hyperthermia
  3. neuroleptic malignant syndrome
17
Q

Dantrolene SE

A
  1. confusion
  2. hepatites
  3. photosensitivity
  4. HF
18
Q

Dantrolene Contra

A
  1. liver disease
  2. cardiac problems
  3. COPD
19
Q

Dantrolene dx-dx

A
  1. ethanol
  2. St. Johns Wort
  3. Kava Kava
20
Q

Dantrolene other

A

CYP3A4 substrate

21
Q

Amitriptylene

A

Tricyclic Antidepressant

22
Q

Amitriptylene MOA

A

Inhibits reuptake of serotonin, NE in CNS

23
Q

Amitryptyline Indication

A
  1. chronic pain
  2. depression
  3. diabetic neuropathy
  4. migraine prophylaxis
24
Q

Amitryptyline SE

A
  1. anticholinergic sxs (urinary retention, tachycardia, hypotension, sedation)
25
Q

Amitryptyline black box warning

A

SUICIDE RISK!

26
Q

Amitriptyline Monitoring

A
  1. Mental status
  2. EKG if heart prob
  3. SI
  4. urinary retention
  5. BP/HR
27
Q

Pilocarpine Class

A

Cholinergic Agent

28
Q

Pilocarpine MOA

A

agonist on muscarinic receptors that stimulates salivary secretion

29
Q

Pilocarpine Indications

A

xerostomia from radiation or Sjorgens

30
Q

Pilocarpine SE

A
  1. dizziness
  2. urinary freq
  3. weakness
  4. sweating
31
Q

Pilocarpine Contra

A
  1. hepatic impairment (child-pugh>10)
  2. asthma
  3. closed-glaucoma (increased IOP)
  4. CVD
  5. COPD
  6. nephrolithiasis

MSK (9 decks)

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