Misc. Pharm

Question 1

Cyclobenzaprine Class

Answer 1

Centrally-acting muscle relaxant

Question 2

Cyclobenzaprine MOA

Answer 2

related to TCAs

reduces tonic somatic motor activity

Question 3

Cyclobenzaprine Indication

Answer 3

muscle spasm

Question 4

Cyclobenzaprine SE

Answer 4

1. antichol effect
2. CNS depression
3. decreased serotonin reuptake
4. xerostomia

Question 5

Cyclobenzaprine Contra

Answer 5

1.

Question 6

Cyclobenzaprine dx-dx

Answer 6

1. increase anti-chol
2. ethanol
3. SSRI
4. Tramadol

Question 7

Cyclobenzaprine Monitor

Answer 7

1. mental
2. serotonin syndrome
3. LFTs

Question 8

Baclofen Class

Answer 8

Centrally-acting muscle relaxant

Question 9

Baclofen MOA

Answer 9

Inhibits transmission of synaptic reflexes @SC level

Question 10

Baclofen Indication

Answer 10

1. MS

2. spinal cord lesions

Question 11

Baclofen SE

Answer 11

1. vertigo
2. psych dist.
3. slurred speech
4. ataxia

Question 12

Baclofen dx-dx

Answer 12

1. increased opioids, benzos, htn-agents
2. increase ethanol, CNS depressants, TCAs
3. clindamycin
4. MAOIs

Question 13

Baclofen Other

Answer 13

Avoid with St. Johns wort, valerian, Kava kava

Question 14

Dantrolene Class

Answer 14

Peripherally-acting muscle relaxant

Question 15

Dantrolene MOA

Answer 15

acts directly on skeletal muscle, inhibits Ca release

Question 16

Dantrolene Indications

Answer 16

1. muscle spasticity due to CVA, CP, SC
2. malignant hyperthermia
3. neuroleptic malignant syndrome

Question 17

Dantrolene SE

Answer 17

1. confusion
2. hepatites
3. photosensitivity
4. HF

Question 18

Dantrolene Contra

Answer 18

1. liver disease
2. cardiac problems
3. COPD

Question 19

Dantrolene dx-dx

Answer 19

1. ethanol
2. St. Johns Wort
3. Kava Kava

Question 20

Dantrolene other

Answer 20

CYP3A4 substrate

Question 21

Amitriptylene

Answer 21

Tricyclic Antidepressant

Question 22

Amitriptylene MOA

Answer 22

Inhibits reuptake of serotonin, NE in CNS

Question 23

Amitryptyline Indication

Answer 23

1. chronic pain
2. depression
3. diabetic neuropathy
4. migraine prophylaxis

Question 24

Amitryptyline SE

Answer 24

1. anticholinergic sxs (urinary retention, tachycardia, hypotension, sedation)

Question 25

Amitryptyline black box warning

Answer 25

SUICIDE RISK!

Question 26

Amitriptyline Monitoring

Answer 26

1. Mental status 2. EKG if heart prob 3. SI 4. urinary retention 5. BP/HR

Question 27

Pilocarpine Class

Answer 27

Cholinergic Agent

Question 28

Pilocarpine MOA

Answer 28

agonist on muscarinic receptors that stimulates salivary secretion

Question 29

Pilocarpine Indications

Answer 29

xerostomia from radiation or Sjorgens

Question 30

Pilocarpine SE

Answer 30

1. dizziness 2. urinary freq 3. weakness 5. sweating

Question 31

Pilocarpine Contra

Answer 31

1. hepatic impairment (child-pugh>10) 2. asthma 3. closed-glaucoma (increased IOP) 4. CVD 5. COPD 6. nephrolithiasis