Gout Meds

Question 1

Colchicine Class

Answer 1

Leukocyte migration inhibitor

Question 2

Colchicine MOA

Answer 2

Inhibits leukocyte migration, phagocytic activity

Question 3

Colchicine Indication

Answer 3

acute gout

Question 4

Colchicine SE

Answer 4

1. myopathy

2. bone marrow suppression

Question 5

Colchicine Contra

Answer 5

1. CKD

2. hepatic disease

Question 6

Colchicine Other

Answer 6

for people who can’t use NSAIDs

low therapeutic index

Question 7

Probenacid Class

Answer 7

Uricosurics

Question 8

Probenacid MOA

Answer 8

blocks PCT reabsorption of uric acid

Question 9

Probenacid SE

Answer 9

1. hepatic toxicity

2. nephtolithiasis

Question 10

Probenacid Contra

Answer 10

1. h/o uric acid stones
2. neuropathy
3. egfr

Question 11

Probenacid dx-dx

Answer 11

1. NSAIDs

2. increases abx

Question 12

Probenacid other

Answer 12

1. counteracted by ASA

2. 5-12 months to decrease gout attacks

Question 13

Allopurinol Class

Answer 13

Xanthine Oxidase Inhibitor

Question 14

Allopurinol MOA

Answer 14

Inhibits xanthine oxidase, blocks uric acid formation

Question 15

Allopurinol Indication

Answer 15

gout prophylaxis

Question 16

Allopurinol SE

Answer 16

1. Stevens-Johnson
2. Hypersensitivty syndrome
3. decrease bone marrow

Question 17

Allopurinol dx-dx

Answer 17

1. theophylline

2. warfarin

Question 18

Allopurinol other

Answer 18

1. long t1/2, accumulates in CKD
2. NOT for acute
3. rash w/ampicillin/amoxicillin
4. don’t treat non-sxs hyperurcemia

Question 19

Febuxostat Class

Answer 19

Nonpurine, Xanthine Oxidase

Question 20

Febuxostat MOA

Answer 20

selectively inhibits xanthine to decrease uric acid production

Question 21

Febuxostat Indication

Answer 21

management of hyperurcemia in gout

Question 22

Febuxostat SE

Answer 22

1. liver fxn

2. arthralgia

Question 23

Febuxostat dx-dx

Answer 23

1. increase azathioprine, theophylline

Question 24

Febuxostate Other

Answer 24

use NSAID or colchine as bridge for first 6 months