Biologic DMARD

Question 1

Etanercept Class

Answer 1

Biologic DMARD

Question 2

Etanercept MOA

Answer 2

TNF alpha-blocker

Question 3

Etanercept Indication

Answer 3

1. aggressive RA

2. non-responsive to NB-DMARDs

Question 4

Etanercept SE

Answer 4

1. reactivation of hepatitis
2. TB
3. lymphoma

Question 5

Etanercept Contra

Answer 5

1. live vaccines
2. demyelinating disorders
3. HF

Question 6

Etanercept dx-dx

Answer 6

echinacea decrease effect

Question 7

Etanercept other

Answer 7

NOT with anakinra

-1-4 weeks to improvement

Question 8

Abatacept Class

Answer 8

Biologic DMARD

Question 9

Abatacept MOA

Answer 9

inhibits T cells by binding CD80, CD86 on APC

Question 10

Abatacept Indication

Answer 10

RA not responding to DMARDs

Question 11

Abatacept SE

Answer 11

1. HTN

2. Infection

Question 12

Abatacept Other

Answer 12

1. false elevated BS (on day of infusion)
2. decreased effectivenss of dead viruses
3. IV INFUSION ONLY

Question 13

Rituximab Class

Answer 13

B-DMARD: monoclonal antibody

Question 14

Rituximab MOA

Answer 14

reduces inflammation by inhibiting B cells (CD20)

Question 15

Rituximab Indications

Answer 15

1. severe RA in COMBO WITH MTX when TNF agents inadequate
2. lymphocytic leukemia
3. non-Hodgkins lymphoma
4. Wegners Granulomatosis

Question 16

Rituximab SE

Answer 16

1. rash w/infusion
2. edema/htn
3. cytopenia

Question 17

Rituximab prescreen

Answer 17

1. hep B/C
2. TB
3. HIV

Question 18

Rituximab monitor

Answer 18

1. CD20

2. cardiac during infusion

Question 19

Anakinra Class

Answer 19

Biologic DMARD

Question 20

Anakinra MOA

Answer 20

naturally occuring antagonist of IL-1

Question 21

Anakinra Indication

Answer 21

RA unresponsive to one or more DMARDs

Question 22

Anakinra SE

Answer 22

1. infection (38%)
2. injection site rxn
3. neutropenia (decreased WBC)

Question 23

Anakinra dx-dx

Answer 23

lots!!

Question 24

Anakinra other

Answer 24

CAN be used with NB-DMARD