Pharm: psoriasis and acne

Question 1

Anti-TNF mAb antibody MOAs

Answer 1

Binds TNF alpha, prevents it from binding its endogenous ligands

Question 2

Anti-TNF mAb admins.

Answer 2

Adalimumab: SC, Etanercept: SC, Infliximab: IV

Question 3

Anti-TNF mAb BBWs

Answer 3

Infection (including fungal, mycobacterial, viral), neoplasia, TB

Question 4

Adalimumab structure

Answer 4

Human monoclonal antibody

Question 5

Etanercept structure

Answer 5

p75 TNF receptor fused to IgG1 Fc

Question 6

Infliximab structure

Answer 6

Fab region of mouse antibody fused to Fc region of human IgG1

Question 7

Infliximab absolute contraindications

Answer 7

Heart failure, murine protein hypersensitivity

Question 8

Etanercept absolute contraindications

Answer 8

Sepsis

Question 9

Anti-TNF antibody interactions (what should you never use the mAbs with?)

Answer 9

Immunosuppressives, vaccines

Question 10

Ustekinumab MOA

Answer 10

Binds p40 subunit, which is important for IL12 and IL23 activation (both are overexpressed in psoriasis plaques), suppresses formation of Th1 and Th17 cells

Question 11

Ustekinumab adverse effects

Answer 11

Increased risk for infections, neoplasia, anaphylaxis

Question 12

Ustekinumab contraindications

Answer 12

Live virus vaccines