Micro: VZV/HHV-6/HHV-7

Question 1

Genome of VZV

Answer 1

Linear dsDNA

Question 2

Genome of HHV 6/7

Answer 2

Linear dsDNA

Question 3

Structure of VZV

Answer 3

Icosahedral capsid, envelepoed

Question 4

Structure of HHV-6/7

Answer 4

Icosahedral capsid, enveloped

Question 5

Disease(s) caused by VZV

Answer 5

Chicken pox (primary infection), shingles (aka zoster) (reactivation)=

Question 6

VZV latency location

Answer 6

Dorsal root ganglion (sensory neurons)

Question 7

VZV clinical presentation of primary infection

Answer 7

Fever followed by itchy rash (starts on scalp, trunk, spreads to limbs, but limbs don’t end up as heavily affected)

Question 8

VZV clinical presentation of reactivation

Answer 8

Shingles: Sudden onset pain in thoracic or facial dermatome. vesicular rash distributed in a dermatomal pattern. Rash may last 2-4 weeks. Pain can last much longer than rash (postherpetic neuralgia)

Question 9

Treatment of shingles

Answer 9

Acyclovir and steroids, vaccine can lessen or prevent symptoms

Question 10

Treatment of chickenpox

Answer 10

Symptomatically: itchness, aches

Question 11

Disease caused by HHV-6/7

Answer 11

Roseola (aka exanthem subitum, aka 6th disease)

Question 12

Roseola clinical presentaiton

Answer 12

Mostly in kids 3-6 months old. Mild resp. illness –> high fever. After fever, rash on face and body (rash lasts 2-3 days). Rash moves from neck/trunk to extremities.

Question 13

VZV pathogenesis

Answer 13

Infection –> viral replication in regional lymph nodes –> primary viremia (at day 4-6) –> viral replication in other organs –> secondary viremia –> infection of skin, appearance of rash (day 14)