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Derm > Pharm: derm conventional chemo drugs > Flashcards

Pharm: derm conventional chemo drugs Flashcards

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Dermatology Board Prep flashcards
1
Q

Carmustine MOA

A

Alkylation of DNA and carbamoylation of amino acids

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2
Q

Cisplatin MOA

A

Intrastrand crosslinks and adducts

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3
Q

Cyclophosphamide MOA

A

Prodrug: alkylating agent

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4
Q

Dacarbazine MOA

A

Prodrug: alkylating agent

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5
Q

Dactinomycin MOA

A

DNA intercalator

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6
Q

Docetaxel MOA

A

Taxane: microtubule stabilizer (inhibits depolymerization)

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7
Q

Doxorubicin MOA

A

Intercalator, free radical generator, topo II inhibitor

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8
Q

Fluorouracil MOA

A

Thymidylate synthase inhibitor (interferes with RNA and RNA synthesis

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9
Q

Lomustine MOA

A

Alkylating agent

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10
Q

Methotrexate MOA

A

DHFR inhibitor

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11
Q

Vinblastine MOA

A

Vinca alkaloid: inhibits microtubule formation

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12
Q

Carmustine adverse effects

A

Dose limiting myelosuppression, secondary malignancy

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13
Q

Cisplatin adverse effects

A

Dose limiting nephrotoxicity. Also, myelosuppression and secondary malignancy

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14
Q

Cyclophosphamide adverse effects

A

DLM, secondary malignancy

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15
Q

Dacarbazine adverse effects

A

DLM

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16
Q

Dactinomycin adverse effects

A

DLM, secondary malignancy

17
Q

Docetaxel adverse effects

A

dose limiting neutropenia. Also, secondary malignancies

18
Q

Doxorubicin adverse effects

A

DLM, secondary malignancies

19
Q

Fluorouracil adverse effects

A

DLM

20
Q

Lomustine adverse effects

A

DLM, secondary malignancies

21
Q

Methotrexate adverse effects

A

DLM

22
Q

Vinblastine adverse effects

A

DLM

23
Q

Monitoring for all chemo drugs except cisplatin

A

CBC

24
Q

Cisplatin monitoring

A

Renal function and CBC

25
Q

Drugs used for basal cell carcinoma

A

Cisplatin, cyclophosphamide, doxorubicin, fluorouracil, methotrexate, vinblastine

26
Q

Drugs used for squamous cell carcinoma

A

Cisplatin

27
Q

Drugs used for melanoma

A

Carmustine, dacarbazine, dactinomycin, docetaxel, lumustine, vinblastine

28
Q

Drugs used for actinic keratosis

A

Fluorouracil

Derm (9 decks)

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