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Board questions > Pharm Misc > Flashcards

Pharm Misc Flashcards

1
Q

Clinical use of Penicillin G, V?

Bactericidal or bacteriostatic?

AE? (general)

A
  • g+ (S. pna, S. pyo, Actinomyces), g- cocci (N. meningitidis), spirochetes (Treponema)
  • bactericidal
  • hypersensitivity reactions, direct coombs + hemolytic anemia
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2
Q

Penicillinase-sensitive penicillins? (2)

Which has greater oral bioavailability?

Clinical use?

A
  • amoxicillin (better oral bioavailability)
  • ampicillin
  • H. influ, H. pylori, E. coli, Listeria, Proteus, Salmonella, Shigella, enterococci
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3
Q

Penicillinase-resistant penicillins (3)?

How?

Clinical use?

A
  • Nafcillin, dicloxacillin, oxacillin
  • bulky R group blocks access of beta lactamase to beta lactam ring
  • S. aureus (MSSA)
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4
Q

Anti-pseudomonal penicillins? (2)

Clinical use?

A

Piperacillin, ticarcillin

Pseudomonas, g- rods, use with beta lactamase inhibitors

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5
Q

beta lactamse inhibitors (4)

A

clavulanic acid

avibactam

sulbactam

tazobactam

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6
Q

what drugs are focal to massive hepatic necrosis?

A

HAVAc

  • Halothane
  • Amanita phalloides (death cap mushroom)
  • Valproic acid
  • Acetaminophen
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7
Q

Drugs causing pancreatitis?

A

Drugs Causing A Violent Abdominal Distress

  • Didanosine
  • Corticosteroids
  • Alcohol
  • Valproic acid
  • Azathioprine
  • Diuretics (furosemide, HCTZ)
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8
Q

Drugs causing agranulocytosis?

A

Can Cause Pretty Major Collapse of Granulocytes

  • Clozapine
  • Carbamazepine
  • Propylthiouracil
  • Methimazole
  • Colchicine
  • Ganciclovir
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9
Q

Drugs that can cause aplastic anemia?

A

Can’t Make New Blood Cells Properly

  • Carbamazepine
  • Methimazole
  • NSAIDs
  • Benzene
  • Chloramphenicol
  • Propylthiouracil
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10
Q

Drug reaction with eosinophilia and systemic symptoms (DRESS) delayed HS rxn

A

allopurinol, anticonvulsants, abxs, sulfa drugs

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11
Q

Hemolysis in G6PD deficiency can be brought on by what drugs?

A

hemolysis IS D PAIN

  • Isoniazid
  • Sulfonamides
  • Dapsone
  • Primaquine
  • Aspirin
  • Ibuprofen
  • Nitrofurantoin
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12
Q

Drugs causing megaloblastic anemia?

A

Hydroxyurea, Phenytoin, Methotrexate, Sulfa drugs

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13
Q

drugs precipitating hyperuricemia and/or gout

A

Painful Tophi and Feet Need Care

  • Pyrazinamide
  • Thiazides
  • Furosemide
  • Niacin
  • Cyclosporine
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14
Q

What drugs can cause SLE like ssx?

A

Sulfa drugs, Hydralazine, Isoniazid, Procainamide, Phenytoin, Etanercept

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15
Q

What drugs have seizures as a major AE?

A

with seizures I BITE my tongue

  • Isoniazid (B6 deficiency)
  • Buproprion
  • Imipenem/cilastatin
  • Tramadol
  • Enflurane
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16
Q

What drugs cause pulmonary fibrosis?

A

My Nose Cannot Breathe Bad Air

  • Methotrexate
  • Nitrofurantoin
  • Carmustine
  • Bleomycin
  • Bulsulfan
  • Amiodarone
17
Q

Drugs that cause Disulfram like reactions

A

Sorry Pals, Can’t Go Mingle

  • Sulfonylureas first gen
  • Procarbazine
  • Cephalosporins (some)
  • Griseofulvin
  • Metronidazole
18
Q
A
19
Q

Inducers of Cytochrome P450

A

Chronic alcoholics Steal Phen Phen and Never Refuse Greasy Carbs

  • Chronic alcohol use
  • St. Johns wart
  • Phenytoin
  • Phenobarbital
  • Nevirapine
  • Rifampin
  • Griseofulvin
  • Carbamazepine
20
Q

Substrates of cytochrome P450

A

Always Think When Outdoors

  • Antiepileptics
  • Theophylline
  • Warfarin
  • OCPs
21
Q

Inhibitors of cytochrome P450

A

SICKFACES.COM

  • Sodium valproate
  • Isoniazid
  • Cimetidine
  • Ketoconazole
  • Fluconazole
  • Acute alcohol abuse
  • Chloramphenicol
  • Erythromyocin (macrolides)
  • Sulfonamides
  • Ciprofloxacin
  • Omeprazole
  • Metronidazole
22
Q

Sulfa drugs include

A

Scary Sulfa Pharm FACTS

  • Sulfonamide abx
  • Sulfasalazine
  • Probenecid
  • Furosemide
  • Acetazolamide
  • Celecoxib
  • Thiazides
  • Sulfonylureas

Board questions (24 decks)

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