Combank 4 Flashcards

1
Q

What will cells in CML stain for or be negative for?

How do you tx CML?

A

negative leukocyte alkaline phosphatase stain

blasts are myeloperoxidase negative

tx with imatinib

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2
Q

tartate-resistant acid phosphatase test confirms what dx?

A

hairy cell leukemia

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3
Q

tx of tinea versicolor

A

selenium sulfide lotion alone or in combo with oral antifungals

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4
Q

What nerves does the corneal reflex test?

Which area of the skull do these go through?

A

CN V and VII

afferent is trigeminal (superior orbital fissure (V1)) and efferent is facial (stylomastoid foramen)

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5
Q

What is the only muscle of the tongue not innervated by the hypoglossal nerve?

A

palatoglossus innervated by vagus

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6
Q

the only motor output of the glossopharyngeal nerve is to the

A

stylopharyngeus muscle

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7
Q

tamoxifen location of actions

A

ER antagonist on breast tissue, but it acts as a partial agonist on the endometrium, thereby increasing the risk of endometrial hyperplasia, polyps, and cancer

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8
Q

tx of neuroleptic malignant syndrome

A

dantrolene and dopamine agonists such as bromocriptine

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9
Q

What does irreversible inhibition do to Vmax?

What does competitive inhibition do to Km?

A

decreases Vmax

increases Km

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10
Q

a pleural effusion from CHF is going to be..,

A

transudative

transudate is passively secreted because of high hydrostatic pressure and not from tissue damage

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11
Q

tx for serotonin syndrome

A

cyproheptadine

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12
Q

MC type of primary ovarian malignancy?

A

papillary serous tumors

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13
Q

What innervates the pronator teres?

A

median nerve

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14
Q

How does spironolactone cause gynecomastia?

A

blocks androgen receptors

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15
Q

MOA of cromolyn, zafirlukast/montelukast, and zileuton

A
  • cromolyn is mast cell degranulation inhibitor
  • zafirlukast and montelukast are leukotriene receptor antagonists
  • zileuton prevents leukotriene synthesis by inhibiting 5-lipoxygenase
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16
Q

tx for bubonic plague

A

streptomycin, aminoglycoside abx that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit of bacteria

inhibits the formation of the initiation complex and leads to misreading of the mRNA

AE: nephrotoxicity and ototoxicity

17
Q

What do you tx cholinesterase inhibitor poisoning with?

A

atropine is first line then use pralidoxime

18
Q

bombesin is a tumor marker for

A

neuroblastoma

19
Q

carcinoembryonic antigen is a tumor marker for

A

colorectal, gastric, and pancreatic cancers

20
Q

Hep B and C predispose to hepatocellular carcinoma - what is a tumor marker for this?

A

alpha-fetoprotein