Combank 4 Flashcards
What will cells in CML stain for or be negative for?
How do you tx CML?
negative leukocyte alkaline phosphatase stain
blasts are myeloperoxidase negative
tx with imatinib
tartate-resistant acid phosphatase test confirms what dx?
hairy cell leukemia
tx of tinea versicolor
selenium sulfide lotion alone or in combo with oral antifungals
What nerves does the corneal reflex test?
Which area of the skull do these go through?
CN V and VII
afferent is trigeminal (superior orbital fissure (V1)) and efferent is facial (stylomastoid foramen)
What is the only muscle of the tongue not innervated by the hypoglossal nerve?
palatoglossus innervated by vagus
the only motor output of the glossopharyngeal nerve is to the
stylopharyngeus muscle
tamoxifen location of actions
ER antagonist on breast tissue, but it acts as a partial agonist on the endometrium, thereby increasing the risk of endometrial hyperplasia, polyps, and cancer
tx of neuroleptic malignant syndrome
dantrolene and dopamine agonists such as bromocriptine
What does irreversible inhibition do to Vmax?
What does competitive inhibition do to Km?
decreases Vmax
increases Km
a pleural effusion from CHF is going to be..,
transudative
transudate is passively secreted because of high hydrostatic pressure and not from tissue damage
tx for serotonin syndrome
cyproheptadine
MC type of primary ovarian malignancy?
papillary serous tumors
What innervates the pronator teres?
median nerve
How does spironolactone cause gynecomastia?
blocks androgen receptors
MOA of cromolyn, zafirlukast/montelukast, and zileuton
- cromolyn is mast cell degranulation inhibitor
- zafirlukast and montelukast are leukotriene receptor antagonists
- zileuton prevents leukotriene synthesis by inhibiting 5-lipoxygenase
tx for bubonic plague
streptomycin, aminoglycoside abx that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit of bacteria
inhibits the formation of the initiation complex and leads to misreading of the mRNA
AE: nephrotoxicity and ototoxicity
What do you tx cholinesterase inhibitor poisoning with?
atropine is first line then use pralidoxime
bombesin is a tumor marker for
neuroblastoma
carcinoembryonic antigen is a tumor marker for
colorectal, gastric, and pancreatic cancers
Hep B and C predispose to hepatocellular carcinoma - what is a tumor marker for this?
alpha-fetoprotein
