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Board questions > genes first aid > Flashcards

genes first aid Flashcards

1
Q

makes receptor tyrosine kinase

a/w lung adenocarcinoma

A

ALK oncogene

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2
Q

makes tyrosine kinase

a/w CML, ALL

A

BCR-ABL oncogene

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3
Q

antiapoptotoic molecule

a/w follicular and diffuse large B cell lymphomas

A

BCL-2 oncogene

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4
Q

makes serine/threonine kinase

a/w melanoma, non-Hodgkin lymphoma, papillary thyroid carcinoma

A

BRAF oncogene

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5
Q

makes cytokine receptor

a/w gastrointestinal stromal tumor (GIST)

A

c-KIT oncogene

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6
Q

makes transcription factor

a/w Burkitt lymphoma

A

c-MYC oncogene

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7
Q

makes receptor tyrosine kinase

a/w breast and gastric carcinomas

A

HER2/neu (c-erbB2) oncogene

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8
Q

makes tyrosine kinase

a/w chronic myeloproliferative disorders

A

JAK2 oncogene

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9
Q

makes GTPase

a/w colon cancer, lung cancer, pancreatic cancer

A

KRAS oncogene

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10
Q

makes transcription factor

a/w lung tumor

A

MYCL1 oncogene

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11
Q

makes transcription factor

a/w neuroblastoma

A

MYCN oncogene

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12
Q

makes receptor tyrosine kinase

a/w MEN2A and 2B, medullary thyroid cancer

A

RET oncogene

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13
Q

negative regulator of Beta-catenin/WNT pathway

a/w colorectal cancer (a/w FAP)

A

APC tumor suppressor gene

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14
Q

DNA repair protein

a/w breast, ovarian, and pancreatic cancer

A

BRCA1/BRCA2 tumor suppressor genes

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15
Q

p16, blocks G1 to S phase

a/w melanoma, pancreatic cancer

A

CDKN2A tumor suppressor gene

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16
Q

DCC (deleted in colon cancer)

a/w colon cancer

A

DCC tumor suppressor gene

17
Q

Deleted in pancreatic cancer

A

DPC4/SMAD4 tumor suppressor gene

18
Q

menin gene product

A

MEN 1 tumor suppressor gene

19
Q

neurofibromin (Ras GTPase activating protein)

neurofibromatosis type 1

A

NF1

20
Q

Merlin (schwannomin) protein

neurofibromatosis type 2

A

NF2

21
Q

tyrosine phosphatase of PIP3 (eg protein kinase B [AKT] activation)

a/w breast cancer, prostate cancer, endometrial cancer

A

PTEN tumor suppressor gene

22
Q

inhibits E2F; blocks G1 to S phase

a/w retinoblastoma, osteosarcoma

A

Rb tumor suppressor gene

23
Q

p53, activates p21, blocks G1 to S phase

a/w most human cancers, Li-Fraumeni syndrome (multiple malignancies at early age, aka SBLA cancer syndrome - sarcoma, breast, leukemia, adrenal gland)

A

TP53 tumor suppressor gene

24
Q

hamartin protein

a/w tuberous sclerosis

A

TSC 1 tumor suppressor gene

25
Q

tuberin protein

a/w tuberous sclerosis

A

TSC 2 tumor suppressor gene

26
Q

inhibits hypoxia inducible factor 1a

a/w von Hippel-Lindau disease

A

VHL tumor suppressor gene

27
Q

transcription factor that regulates urogenital development

a/w Wilm’s Tumor (nephroblastoma)

A

WT1 tumor suppressor gene

28
Q

mets to bone or liver, Paget disease of bone, seminoma

serum marker?

A

ALP/alkaline phosphatase

29
Q

hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor

serum marker?

A

alpha fetoprotein

30
Q

hydatiform moles and choriocarcinomas (gestational trophoblastic disease), testicular cancer, mixed germ cell tumor

serum marker?

A

hCG

31
Q

breast cancer serum markers?

A

CA 15-3/CA 27-29

32
Q

pancreatic adenocarcinoma serum marker?

A

CA19-9

33
Q

ovarian cancer serum marker

A

CA 125

34
Q

medullary thyroid carcinoma (alone and in MEN2A and 2B)

serum marker?

A

calcitonin

35
Q

major association with colorectal cancer and pancreatic cancer

serum marker?

A

CEA (carcinoembryonic antigen)

36
Q

neuroendocrine tumors serum marker?

A

chromogranin

37
Q

p-glycoprotein aka MDR1 is classically seen in what type of carcinoma?

What might this cause in a cancer pt?

A

adrenocortical carcinoma

one mechanism of decreased responsiveness or resistance to chemotherapy over time

Board questions (24 decks)

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