genes first aid

Question 1

makes receptor tyrosine kinase

a/w lung adenocarcinoma

Answer 1

ALK oncogene

Question 2

makes tyrosine kinase

a/w CML, ALL

Answer 2

BCR-ABL oncogene

Question 3

antiapoptotoic molecule

a/w follicular and diffuse large B cell lymphomas

Answer 3

BCL-2 oncogene

Question 4

makes serine/threonine kinase

a/w melanoma, non-Hodgkin lymphoma, papillary thyroid carcinoma

Answer 4

BRAF oncogene

Question 5

makes cytokine receptor

a/w gastrointestinal stromal tumor (GIST)

Answer 5

c-KIT oncogene

Question 6

makes transcription factor

a/w Burkitt lymphoma

Answer 6

c-MYC oncogene

Question 7

makes receptor tyrosine kinase

a/w breast and gastric carcinomas

Answer 7

HER2/neu (c-erbB2) oncogene

Question 8

makes tyrosine kinase

a/w chronic myeloproliferative disorders

Answer 8

JAK2 oncogene

Question 9

makes GTPase

a/w colon cancer, lung cancer, pancreatic cancer

Answer 9

KRAS oncogene

Question 10

makes transcription factor

a/w lung tumor

Answer 10

MYCL1 oncogene

Question 11

makes transcription factor

a/w neuroblastoma

Answer 11

MYCN oncogene

Question 12

makes receptor tyrosine kinase

a/w MEN2A and 2B, medullary thyroid cancer

Answer 12

RET oncogene

Question 13

negative regulator of Beta-catenin/WNT pathway

a/w colorectal cancer (a/w FAP)

Answer 13

APC tumor suppressor gene

Question 14

DNA repair protein

a/w breast, ovarian, and pancreatic cancer

Answer 14

BRCA1/BRCA2 tumor suppressor genes

Question 15

p16, blocks G1 to S phase

a/w melanoma, pancreatic cancer

Answer 15

CDKN2A tumor suppressor gene

Question 16

DCC (deleted in colon cancer)

a/w colon cancer

Answer 16

DCC tumor suppressor gene

Question 17

Deleted in pancreatic cancer

Answer 17

DPC4/SMAD4 tumor suppressor gene

Question 18

menin gene product

Answer 18

MEN 1 tumor suppressor gene

Question 19

neurofibromin (Ras GTPase activating protein)

neurofibromatosis type 1

Answer 19

NF1

Question 20

Merlin (schwannomin) protein

neurofibromatosis type 2

Answer 20

NF2

Question 21

tyrosine phosphatase of PIP3 (eg protein kinase B [AKT] activation)

a/w breast cancer, prostate cancer, endometrial cancer

Answer 21

PTEN tumor suppressor gene

Question 22

inhibits E2F; blocks G1 to S phase

a/w retinoblastoma, osteosarcoma

Answer 22

Rb tumor suppressor gene

Question 23

p53, activates p21, blocks G1 to S phase

a/w most human cancers, Li-Fraumeni syndrome (multiple malignancies at early age, aka SBLA cancer syndrome - sarcoma, breast, leukemia, adrenal gland)

Answer 23

TP53 tumor suppressor gene

Question 24

hamartin protein

a/w tuberous sclerosis

Answer 24

TSC 1 tumor suppressor gene

Question 25

tuberin protein a/w tuberous sclerosis

Answer 25

TSC 2 tumor suppressor gene

Question 26

inhibits hypoxia inducible factor 1a a/w von Hippel-Lindau disease

Answer 26

VHL tumor suppressor gene

Question 27

transcription factor that regulates urogenital development a/w Wilm's Tumor (nephroblastoma)

Answer 27

WT1 tumor suppressor gene

Question 28

mets to bone or liver, Paget disease of bone, seminoma serum marker?

Answer 28

ALP/alkaline phosphatase

Question 29

hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor serum marker?

Answer 29

alpha fetoprotein

Question 30

hydatiform moles and choriocarcinomas (gestational trophoblastic disease), testicular cancer, mixed germ cell tumor serum marker?

Answer 30

hCG

Question 31

breast cancer serum markers?

Answer 31

CA 15-3/CA 27-29

Question 32

pancreatic adenocarcinoma serum marker?

Answer 32

CA19-9

Question 33

ovarian cancer serum marker

Answer 33

CA 125

Question 34

medullary thyroid carcinoma (alone and in MEN2A and 2B) serum marker?

Answer 34

calcitonin

Question 35

major association with colorectal cancer and pancreatic cancer serum marker?

Answer 35

CEA (carcinoembryonic antigen)

Question 36

neuroendocrine tumors serum marker?

Answer 36

chromogranin

Question 37

p-glycoprotein aka MDR1 is classically seen in what type of carcinoma? What might this cause in a cancer pt?

Answer 37

adrenocortical carcinoma one mechanism of decreased responsiveness or resistance to chemotherapy over time