genes first aid Flashcards
makes receptor tyrosine kinase
a/w lung adenocarcinoma
ALK oncogene
makes tyrosine kinase
a/w CML, ALL
BCR-ABL oncogene
antiapoptotoic molecule
a/w follicular and diffuse large B cell lymphomas
BCL-2 oncogene
makes serine/threonine kinase
a/w melanoma, non-Hodgkin lymphoma, papillary thyroid carcinoma
BRAF oncogene
makes cytokine receptor
a/w gastrointestinal stromal tumor (GIST)
c-KIT oncogene
makes transcription factor
a/w Burkitt lymphoma
c-MYC oncogene
makes receptor tyrosine kinase
a/w breast and gastric carcinomas
HER2/neu (c-erbB2) oncogene
makes tyrosine kinase
a/w chronic myeloproliferative disorders
JAK2 oncogene
makes GTPase
a/w colon cancer, lung cancer, pancreatic cancer
KRAS oncogene
makes transcription factor
a/w lung tumor
MYCL1 oncogene
makes transcription factor
a/w neuroblastoma
MYCN oncogene
makes receptor tyrosine kinase
a/w MEN2A and 2B, medullary thyroid cancer
RET oncogene
negative regulator of Beta-catenin/WNT pathway
a/w colorectal cancer (a/w FAP)
APC tumor suppressor gene
DNA repair protein
a/w breast, ovarian, and pancreatic cancer
BRCA1/BRCA2 tumor suppressor genes
p16, blocks G1 to S phase
a/w melanoma, pancreatic cancer
CDKN2A tumor suppressor gene
DCC (deleted in colon cancer)
a/w colon cancer
DCC tumor suppressor gene
Deleted in pancreatic cancer
DPC4/SMAD4 tumor suppressor gene
menin gene product
MEN 1 tumor suppressor gene
neurofibromin (Ras GTPase activating protein)
neurofibromatosis type 1
NF1
Merlin (schwannomin) protein
neurofibromatosis type 2
NF2
tyrosine phosphatase of PIP3 (eg protein kinase B [AKT] activation)
a/w breast cancer, prostate cancer, endometrial cancer
PTEN tumor suppressor gene
inhibits E2F; blocks G1 to S phase
a/w retinoblastoma, osteosarcoma
Rb tumor suppressor gene
p53, activates p21, blocks G1 to S phase
a/w most human cancers, Li-Fraumeni syndrome (multiple malignancies at early age, aka SBLA cancer syndrome - sarcoma, breast, leukemia, adrenal gland)
TP53 tumor suppressor gene
hamartin protein
a/w tuberous sclerosis
TSC 1 tumor suppressor gene
tuberin protein
a/w tuberous sclerosis
TSC 2 tumor suppressor gene
inhibits hypoxia inducible factor 1a
a/w von Hippel-Lindau disease
VHL tumor suppressor gene
transcription factor that regulates urogenital development
a/w Wilm’s Tumor (nephroblastoma)
WT1 tumor suppressor gene
mets to bone or liver, Paget disease of bone, seminoma
serum marker?
ALP/alkaline phosphatase
hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor
serum marker?
alpha fetoprotein
hydatiform moles and choriocarcinomas (gestational trophoblastic disease), testicular cancer, mixed germ cell tumor
serum marker?
hCG
breast cancer serum markers?
CA 15-3/CA 27-29
pancreatic adenocarcinoma serum marker?
CA19-9
ovarian cancer serum marker
CA 125
medullary thyroid carcinoma (alone and in MEN2A and 2B)
serum marker?
calcitonin
major association with colorectal cancer and pancreatic cancer
serum marker?
CEA (carcinoembryonic antigen)
neuroendocrine tumors serum marker?
chromogranin
p-glycoprotein aka MDR1 is classically seen in what type of carcinoma?
What might this cause in a cancer pt?
adrenocortical carcinoma
one mechanism of decreased responsiveness or resistance to chemotherapy over time
