Pharm: Mgmt of Electrical Cardiac Dysfunction Flashcards

1
Q

Na+ channel blockers (2)

class I/V

A

Quinidine and Lidocaine

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2
Q

Beta blockers

class II/V

A

Atenolol (any -olols)

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3
Q

K+ channel blockers (2)

class III/V

A

Amiodarone; sotalol

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4
Q

Ca2+ channel blocker

class IV/V

A

Diltiazem

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5
Q

Na+ channel class 1A blockers __?__ PR and QRS, slowing the rate in rise of phase __?__

A

Pronlong PR and QRS; slow the rate in rise of phase 0

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6
Q

What drug is most commonly used to treat A-fib/flutter in horses?

A

Quinidine

Na+ channel blocker

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7
Q

What arrhythmia can Quinidine cause and how?

A

Supraventricular tachycardia via anti-vagal tone effect (atropine-like)

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8
Q

How can quinidine be used in favor of digoxin?

A

Quinidine inhibits p-glycoprotein pumps –> increased digoxin serum concentrations by two-fold

recall: p-glycoprotein enhances elimination of drugs in kidneys/liver via excretion thru urine/bile

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9
Q

Class 1b Na2+ channel blocker indication

lidocaine, mexiletine

A

acute ventricular tachycardias

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10
Q

MoA of beta blockers

A

reduce sympathetic activity; reduce sinus atrial node rate and AV conduction

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11
Q

Atenolol works at what receptor?

A

Seletively blocks Beta-1 (resulting in decreased cardiac contractility, HR and CO)

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12
Q

Why should beta blockers be avoided in CHF patients?

esp Atelolol

A

B/c in CHF, the SNS is stimulated as a compensatory response –> sudden blockade of this response with beta blocker can lead to decompensation & worsen CHF

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13
Q

Sotalol MoA/uses

A
  • non-selective beta-blocking activity + delay repolarization (phase 3) –> increase AP duration and the refractory (recovery in b/w consec. beats) period
  • long-term tx for ventricular arrhythmias with sig. hemodynamic aspect
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14
Q

Describe Diltiazem’s MoA as a Ca2+ channel blocker

A

blocks calcium channels at at SA and AV nodes, reducing sinus rate

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15
Q

Clinical use of Diltiazem in dogs/cats

A

rate control of supraventricular arrhythmias ONLY (e.g., atrial fibrillation)

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