Pharm- Lung disease

Question 1

Short acting beta agonist- Indications

Answer 1

• Asthma: Immediate relief of symptoms- most effective med for acute bronchospasm
• Intermediate duration- 3-6 hrs
• Only for use <2x/ week
  COPD: Long term use for bronchodilation

Question 2

Short acting beta agonist- MOA

Answer 2

Relaxes bronchial smooth muscle- beta 2 agonist

Question 3

Short acting beta agonist- AE

Answer 3

• Nervousness, tremor, HA, palpitations

Question 4

Short acting beta agonist- Names

Answer 4

Albuterol, levalbuterol, metaproternol

Question 5

Long acting beta agonist- Names

Answer 5

salmeterol, formoterol

Question 6

Long acting beta agonist- Indications

Answer 6

• Long acting relief of symptoms- not control

Question 7

Long acting beta agonist- MOA

Answer 7

• Long acting beta agonist- relaxes bronchial smooth muscle

Question 8

Long acting beta agonist- AE

Answer 8

• Black box: Increased risk of death if used as long term controller

Question 9

Mast cell stabilizers- Names

Answer 9

Cromolyn

Question 10

Leukotriene modifiers- Names

Answer 10

montelukast, zafirlukast, zileuton

Question 11

Leukotriene modifiers- Indications

Answer 11

Alternative controller for concern about steroids in children

Question 12

Mast cell stabilizers- MOA

Answer 12

Inhibit inflammatory response of mast cells in lungs

Question 13

Inhaled corticosteroids- Names

Answer 13

beclomethasone, fluticasone, triamcinolone

Question 14

Inhaled corticosteroids- AE

Answer 14

• Low side effect profile

- HPA axis may be suppressed in children, reducing growth

Question 15

Anticholinergics- MOA

Answer 15

Block Ach to allow relaxation of bronchial smooth muscle

Question 16

Anticholinergics- Names

Answer 16

ipatropium, tiotropium

Question 17

Anticholinergics- Indications

Answer 17

COPD- allows chronic bronchodilation

Question 18

Anticholinergics- AE

Answer 18

• Dry mouth and oropharynx

- No systemic anticholinergic side effects

Question 19

Inhaled corticosteroids- Indications

Answer 19

Low dose- beginning at Asthma step 2

Question 20

Inhaled corticosteroids- MOA

Answer 20

Decrease underlying airway inflammation- eosinophils, marcophages, T- lymphocytes

Question 21

Mast cell stabilizers- AE

Answer 21

Irritation, dry throat, bitter taste

Question 22

Phosphodiesterase inhibitor- Theophylline- Indications

Answer 22

Alternative treatment in asthma/ COPD

Question 23

Phosphodiesterase inhibitor- Theophylline- MOA

Answer 23

Antagonizes adenosine receptors- increases cAMP

Question 24

Phosphodiesterase inhibitor- Theophylline- AE

Answer 24

N/V/HA insomnia

Question 25

Leukotriene modifiers- MOA

Answer 25

Blocks leukotriene pathway of inflammation

Question 26

Leukotriene modifiers- AE

Answer 26

HA, URI, fever, influenza sx, abd pain

Question 27

Systemic corticosteroids- Names

Answer 27

Dexamethasone, prednisone, solumedorl

Question 28

Systemic corticosteroids-Indications

Answer 28

Short- 5 days burst following acute exacerbation with incomplete/ poor response to albuterol

Question 29

Systemic corticosteroids-AE

Answer 29

HPA axis supression, cataracts, striae