Pharm: Heme Drugs

Question 0

Fondaparinux

Answer 0

Promotes inhibition of factor Xa by anti-thrombin III

Question 1

Heparin

Answer 1

Promotes action of anti-thrombin III

Question 2

Warfarin (Coumadin)

Answer 2

Inhibits vitamin K-dependent carboxylation of factors II, VII, IX, X and proteins C and S

Question 3

Argatroban

Answer 3

Direct thrombin inhibitor (others in this class: bivalirudin, lepirudin)

Question 4

Rivaroxaban

Answer 4

Director inhibitor of factor Xa

Question 5

ASA (Aspirin)

Answer 5

Irreversible inhibitor of COX1 and 2 > decreased prostaglandin synthesis

Question 6

Clopidogrel

Answer 6

Blocks platelet aggregation by irreversibly inhibiting binding of ADP to P2Y12 receptor (other drugs in same class: prasugrel)

Question 7

Cilostazol

Answer 7

Inhibits cAMP phosphodiesterase III > increased cAMP levels > inhibits thromboxane A2 synthesis

Question 8

Dipyridamole

Answer 8

Inhibits uptake of adenosine > increases circulating adenosine > increases cAMP > inhibits thromboxane A2 synthesis

Question 9

Abciximab

Answer 9

Inhibits glycoprotein IIb/IIIa > inhibits binding of fibrinogen and vWF

Question 10

Streptokinase

Answer 10

Promotes conversion of plasminogen to plasmin (thrombolytic)

Question 11

Aminocaproic acid

Answer 11

Inhibits plasminogen activation > inhibits fibrinolysis