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Step 1 > Drug Reactions > Flashcards

Drug Reactions Flashcards

1
Q

Long QT / torsades

A

Sotalol, quinidine, macrolides, haldol and risperdal, TCAs

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2
Q

Hyperglycemia

A

Tacrolimus, protease inhibitors, niacin, HCTZ, B blockers, steroids

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3
Q

Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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4
Q

Diarrhea

A

Metformin, erythromycin, colchicine, acarbose

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5
Q

Hepatic necrosis

A

Halothane, valproic acid, Tylenol

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6
Q

Hepatitis

A

Isoniazid

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7
Q

Pancreatitis

A

Didanosine, steroids, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

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8
Q

Agranulocytosis

A

Dapsone, clozapine, carbamazepine, colchicine, methimazole, PTU

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9
Q

Aplastic anemia

A

Carbamazepine, methimazole, PTU, NSAIDs, benzene, chloramphenicol

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10
Q

Hemolytic anemia (direct Coombs +)

A

Methyldopa, penicillin

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11
Q

G6PD hemolysis

A

Isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

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12
Q

Megaloblastic anemia

A

Phenytoin, methotrexate, sulfa drugs

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13
Q

Thrombocytopenia

A

Heparin, cimetidine

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14
Q

Gynecomastia

A

Spironolactone, digitalis, cimetidine, alcohol, ketoconazole

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15
Q

Hyperuricemia (gout)

A

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

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16
Q

Coronary vasospasm

A

Cocaine, sumatriptan, ergots

17
Q

Gingival hyperplasia

A

Phenytoin, verapamil, cyclosporine, nifedipine

18
Q

Myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

19
Q

Photosensitivity

A

Sulfonamides, amiodarone, tetracyclines, 5-FU

20
Q

SJS

A

Anti-epileptics, allopurinol, sulfa drugs, penicillin

21
Q

SLE-like syndrome

A

Sulfas, hydralazine, INH, procainamide, phenytoin, etanercept

22
Q

Seizures

A

INH, bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

23
Q

Fanconi syndrome

A

Expired tetracyclines, heavy metal exposure

24
Q

Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

25
Q

SIADH

A

Carbamazepine, cyclophosphamide, SSRIs

26
Q

Pulmonary fibrosis

A

Amiodarone, bleomycin, methotrexate

27
Q

Nephrotoxicity/ototoxicity

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

28
Q

What are the sulfa drugs?

A

Probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfa abx, sulfasalazine, sulfonylureas

29
Q

Cytochrome P-450 inducers

A

Chronic alcohol use, modafinil, St. John’s wort, phenytoin, phenobarb, nevirapine, rifampin, griseofulvin, carbamazepine

30
Q

Cytochrome P-450 inhibitors

A

Acute alcohol use, gemfibrozil, cipro, INH, grapefruit juice, quinidine, amiodarone, ketoconazole, macrolides, sulfonamides, cimetidine, ritonavir

31
Q

Cytochrome P-450 substrates

A

Anti-epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs

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