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FA: random > Pharm general > Flashcards

Pharm general Flashcards

1
Q

Acetaminophen o/d

A

N-acetylcysteine (replenishes glutathione)

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2
Q

AChE inhibitors, organophosphates o/d

A

Atropine followed by pralidoxime

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3
Q

Amphetamines (basic) o/d

A

NH4Cl (acidify urine)

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4
Q

Antimuscarinic, anticholinergic agents o/d

A

Physostigmine salicylate, control hyperthermia

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5
Q

Benzodiazepines o/d

A

Flumazenil

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6
Q

β-blockers o/d

A

Glucagon

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7
Q

Carbon monoxide o/d

A

100% O2, hyperbaric O2

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8
Q

Copper, arsenic, gold o/d

A

Penicillamine

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9
Q

Cyanide o/d

A

Nitrite + thiosulfate, hydroxocobalamin

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10
Q

Digitalis o/d

A

Anti-dig Fab fragments

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11
Q

Heparin o/d

A

Protamine sulfate

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12
Q

Iron o/d

A

Deferoxamine, deferasirox

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13
Q

Lead o/d

A

EDTA, dimercaprol, succimer, penicillamine

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14
Q

Mercury, arsenic, gold o/d

A

Dimercaprol (BAL), succimer

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15
Q

Methanol, ethylene glycol (antifreeze) o/d

A

Fomepizole > ethanol, dialysis

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16
Q

Methemoglobin o/d

A

Methylene blue, vitamin C

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17
Q

Opioids o/d

A

Naloxone

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18
Q

Salicylates o/d

A

NaHCO3 (alkalinize urine), dialysis

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19
Q

TCAs o/d

A

NaHCO3 (plasma alkalinization)

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20
Q

tPA, streptokinase, urokinase o/d

A

Aminocaproic acid

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21
Q

Warfarin o/d

A

Vitamin K, plasma (if active bleeding)

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22
Q

What Rx causes Coronary vasospasm

A

Cocaine, sumatriptan, ergot alkaloids

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23
Q

What Rx causes Cutaneous flushing

A

Vancomycin, Adenosine, Niacin, Ca2+ channel blockers

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24
Q

What Rx causes Dilated cardiomyopathy

A

Doxorubicin, daunorubicin

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25
Q

What Rx cause Torsades de pointes

A

Class III (e.g., sotalol) and class IA (e.g., quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs

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26
Q

What Rx cause Adrenocortical insufficiency

A

HPA suppression 2° to glucocorticoid withdrawal

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27
Q

What Rx cause Hot flashes

A

Tamoxifen, clomiphene

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28
Q

What Rx cause Hyperglycemia

A

Tacrolimus, Protease inhibitors, Niacin, HCTZ,

β-blockers, Corticosteroids

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29
Q

What Rx cause Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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30
Q

What Rx cause Acute cholestatic hepatitis, jaundice

A

Erythromycin

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31
Q

What Rx cause Diarrhea

A

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose

Might Excite Colon On Accident

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32
Q

What Rx cause Focal to massive hepatic necrosis

A

Halothan, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen

Liver “HAVAc”

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33
Q

What Rx cause Hepatitis

A

INH

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34
Q

What Rx cause Pancreatitis

A

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

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35
Q

What Rx cause Pseudomembranous colitis

A

Clindamycin, ampicillin, cephalosporins

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36
Q

What Rx cause Agranulocytosis

A

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil

Drugs CCCrush Myeloblasts and Promyelocytes

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37
Q

What Rx cause Aplastic anemia

A

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

Can’t Make New Blood Cells Properly

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38
Q

What Rx cause Direct Coombs- positive hemolytic anemia

A

Methyldopa, penicillin

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39
Q

What Rx cause Gray baby syndrome

A

Chloramphenicol

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40
Q

What Rx cause Hemolysis in G6PD deficiency

A

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

hemolysis IS D PAIN

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41
Q

What Rx cause Megaloblastic anemia

A

Phenytoin, Methotrexate, Sulfa drugs

having a “blast” w/ PMS

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42
Q

What Rx cause Thrombocytopenia

A

Heparin, cimetidine

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43
Q

What Rx cause Thrombotic complications

A

OCPs (e.g., estrogens)

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44
Q

What Rx cause Fat redistribution

A

Protease inhibitors, Glucocorticoids

Fat PiG

45
Q

What Rx cause Gingival hyperplasia

A

Phenytoin, verapamil, cyclosporine, nifedipine

46
Q

What Rx cause Hyperuricemia (gout)

A

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

Painful Tophi and Feet Need Care

47
Q

What Rx cause Myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-α, penicillamine, statins, glucocorticoids

48
Q

What Rx cause Osteoporosis

A

Corticosteroids, heparin

49
Q

What Rx cause Photosensitivity

A

Sulfonamides, Amiodarone, Tetracyclines, 5-FU

SAT For Photo

50
Q

What Rx cause Rash (Stevens- Johnson syndrome)

A

Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin

Steven Johnson has epileptic Allergy to Sulfa
drugs and Penicillin

51
Q

What Rx cause SLE-like syndrome

A

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept

having lupus is “SHIPP-E”

52
Q

What Rx cause Teeth discoloration

A

Tetracyclines

53
Q

What Rx cause Tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinolones

54
Q

What Rx cause Cinchonism

A

Quinidine, quinine

55
Q

What Rx cause Parkinson-like syndrome

A

Antipsychotics, Reserpine, Metoclopramide

56
Q

What Rx cause Seizures

A

INH (vitamin B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

57
Q

What Rx cause Tardive dyskinesia

A

Antipsychotics, metoclopramide

58
Q

What Rx cause Diabetes insipidus

A

Lithium, demeclocycline

59
Q

What Rx cause Fanconi syndrome

A

Expired tetracycline

60
Q

What Rx cause Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide

61
Q

What Rx cause Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

62
Q

What Rx cause SIADH

A

Carbamazepine, Cyclophosphamide, SSRIs

63
Q

What Rx cause Dry cough

A

ACE inhibitors

64
Q

What Rx cause Pulmonary fibrosis

A

Bleomycin, Amiodarone, Busulfan, Methotrexate

Breathing Air Badly from Medications

65
Q

What Rx cause Antimuscarinic

A

Atropine, TCAs, H1-blockers, antipsychotics

66
Q

What Rx cause Disulfiram-like reaction

A

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st-generation sulfonylureas


67
Q

What Rx causes Nephrotoxicity/ ototoxicity

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

68
Q

What are the inducers of CYP450?

A 
Chronic alcohol use 
Modafinil
St. John’s wort 
Phenytoin 
Phenobarbital 
Nevirapine 
Rifampin 
Griseofulvin 
Carbamazepine

Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs

69
Q

What are substrates of CYP450?

A 
Anti-epileptics 
Antidepressants 
Antipsychotics 
Anesthetics 
Theophylline 
Warfarin 
Statins
OCPs

Always, Always, Always, Always Think When Starting Others

70
Q

What are the inhibitors of CYP450?

A 
Acute alcohol abuse 
Gemfibrozil 
Ciprofloxacin 
Isoniazid 
Grapefruit juice 
Quinidine 
Amiodarone 
Ketoconazole 
Macrolides 
Sulfonamides 
Cimetidine 
Ritonavir

A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls

71
Q

Name the sulfa drugs

A 
Probenecid, 
Furosemide, 
Acetazolamide, 
Celecoxib, 
Thiazides, 
Sulfonamide antibiotics, 
Sulfasalazine, 
Sulfonylureas.

Popular FACTSSS

72
Q

-azole

A

Ergosterol synthesis inhibitor

73
Q

-bendazole

A

Antiparasitic/antihelmintic

74
Q

-cillin

A

Peptidoglycan synthesis inhibitor

75
Q

-cycline

A

Protein synthesis inhibitor

76
Q

-ivir

A

Neuraminidase inhibitor

77
Q

-navir

A

Protease inhibitor

78
Q

-ovir

A

DNA polymerase inhibitor

79
Q

-thromycin

A

Macrolide antibiotic

80
Q

-ane

A

Inhalational general anesthetic

81
Q

-azine

A

Typical antipsychotic

82
Q

-barbital

A

Barbiturate

83
Q

-caine

A

Local anesthetic

84
Q

-etine

A

SSRI

85
Q

-ipramine

A

TCA

86
Q

-triptan

A

5-HT1B/1D agonists

87
Q

-triptyline

A

TCA

88
Q

-zepam

A

Benzodiazepine

89
Q

-zolam

A

Benzodiazepine

90
Q

-chol

A

Cholinergic agonist

91
Q

-curium or -curonium

A

Non-depolarizing paralytic

92
Q

-olol

A

β-blocker

93
Q

-stigmine

A

AChE inhibitor

94
Q

-terol

A

β2-agonist

95
Q

-zosin

A

α1-antagonist

96
Q

-afil

A

PDE-5 inhibitor

97
Q

-dipine

A

Dihydropyridine CCB

98
Q

-pril

A

ACE inhibitor

99
Q

-sartan

A

Angiotensin-II receptor blocker

100
Q

-statin

A

HMG-CoA reductase inhibitor

101
Q

-dronate

A

Bisphosphonate

102
Q

-glitazone

A

PPAR-γ activator

103
Q

-prazole

A

Proton pump inhibitor

104
Q

-prost

A

Prostaglandin analog

105
Q

-tidine

A

H2-antagonist

106
Q

-tropin

A

Pituitary hormone

107
Q

-ximab

A

Chimeric monoclonal Ab

108
Q

-zumab

A

Humanized monoclonal Ab

FA: random (15 decks)

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