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Immuno memorize Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anti-cardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-dsDNA, anti-Smith

A

SLE

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6
Q

Anti-glutamate decarboxylase

A

Type 1 diabetes mellitus

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7
Q

Anti-hemidesmosome

A

Bullous pemphigoid

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8
Q

Antihistone

A

Drug-induced lupus

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9
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A

Polymyositis, dermatomyositis

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10
Q

Antimicrosomal, antithyroglobulin

A

Hashimoto thyroiditis

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11
Q

Antimitochondrial

A

1° biliary cirrhosis

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12
Q

Antinuclear antibodies

A

SLE, nonspecific

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13
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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14
Q

Anti-smooth muscle

A

Autoimmune hepatitis

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15
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La)

A

Sjögren syndrome

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16
Q

Anti-TSH receptor

A

Graves disease

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17
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

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18
Q

c-ANCA (PR3-ANCA)

A

Granulomatosis with polyangiitis (Wegener)

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19
Q

IgA antiendomysial, IgA anti-tissue transglutaminase

A

Celiac disease

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20
Q

p-ANCA (MPO-ANCA)

A

Microscopic polyangiitis, Churg-Strauss syndrome

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21
Q

Rheumatoid factor (antibody, most commonly IgM, specific to IgG Fc region), anti-CCP

A

Rheumatoid arthritis

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22
Q

Anti-desmoglein

A

Pemphigus vulgaris

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23
Q

IL-1:

A

fever (hot).

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24
Q

IL-2:

A

stimulates T cells.

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25
Q

IL-3:

A

stimulates bone marrow.

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26
Q

IL-4:

A

stimulates IgE production.

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27
Q

IL-5:

A

stimulates IgA production.

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28
Q

IL-6:

A

stimulates acute-phase protein

production.

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29
Q

Splenic dysfunction has susceptibility to which encapsulated organisms?

A 
(SHiNE SKiS):
Streptococcus pneumoniae
Haemophilus influenzae type B 
Neisseria meningitidis
Escherichia coli
Salmonella spp.
Klebsiella pneumoniae
Group B Streptococci
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30
Q

What type of cells may be present postsplenectomy?

A

Howell-Jolly bodies (nuclear remnants)
Target cells
Thrombocytosis

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31
Q

HLA-A3

A

Hemochromatosis

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32
Q

HLA-B27

A 
PAIR => seronegative arthropathies
Psoriatic arthritis
Ankylosing spondylitis
Inflam bowel dz arthriitis
Reactive arthritis (Reiter syndrome)
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33
Q

HLA-DQ2/DQ8

34
Q

HLA-DR2

A

MS, hay fever, SLE, Goodpasture syndrome

35
Q

HLA-DR3

A

DM type I, SLE, Graves

36
Q

HLA-DR4

A

Rheumatoid arthritis, DM type I

37
Q

HLA-DR5

A

Pernicious anemia due to vit B12 deficiency;

Hashimoto thyroiditis

38
Q

What does Th-1 secrete? activate? what inhibits it?

A

Secretes IFN-y
Activates macs & CD8 (CTLs)
Inhibited by IL-4, IL-10 (from Th-2 cell)

39
Q

What does Th-2 secrete? activate? what inhibits it?

A

Secretes IL-4, 5, 6, 13
Recruits eosinophils for parasite defense & promotes IgE production by B cells
Inhibited by IFN-y (from Th-1 cell)

40
Q

Define acute phase reactants

A

factors whose serum [ ] change significantly in response to inflammation => produced by liver in both acute & chronic inflammatory states

41
Q

What induces production of acute phase reactants?

A

IL-6, IL-1, TNF-alpha, IFN-y

42
Q

What acute phase reactants are upregulated in inflammatory states? what is the result?

A

Serum Amyloid A => prolonged elevation leads to amyloidosis
CRP => opsonin; fixes complement & facilitates phagocytosis & measure of ongoing inflammation
Ferritin => binds & sequesters Fe++ to inhibit microbial Fe+ scavenging
Fibrinogen => Coag factor; promotes endothelial repair; correlates w/ ESR
Hepcidin => prevents release of Fe+ bound by ferritin indicating anemia of chronic dz

43
Q

What acute phase reactants are downregulated in inflammatory states? what is the purpose?

A

Albumin => reduction conserves AA for positive reactants

Transferrin => internalized by macrophages to sequester iron

44
Q

C3 deficiency has what affects?

A

Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections;
increases susceptibility to type III hypersensitivity reactions.

45
Q

What is contraindicated in C1 esterase inhibitor deficiency?

A

ACE inhibitors

46
Q

What is the result of DAF (GPI anchored enzyme) deficiency?

A

Causes complement-mediated lysis of RBCs & paroxysmal nocturnal hemoglobinuria.

47
Q

Presentation of type I HSR

A

immediate, anaphylactic, atopic

48
Q

Presentation of type II HSR

A

Dz tends to be specific to tissue or site where antigen is found

49
Q

Presentation of type III HSR

A

can be assoc w/ vasculitis & systemic manifestations

50
Q

presentation of type IV HSR

A

response is delayed & does NOT involve Abs

51
Q

Presentation of bacterial infection w/ no T cells

52
Q

Presentation of bacterial infection w/ no B cells

A

Encapsulated => (SHiNE SKiS)
Streptococcus pneumoniae, Haemophilus influenzae type B, Neisseria meningitidis, Escherichia coli, Salmonella, Klebsiella pneumoniae, group B Strep

53
Q

Presentation of bacterial infection w/ no granulocytes

A

Staphylococcus, Burkholderia cepacia, Serratia, Nocardia

54
Q

Presentation of bacterial infection w/ no complement

A

Neisseria (no membrane attack complex)

55
Q

Presentation of viral infection w/ no T cells

A

CMV, EBV, JCV, VZV chronic infection with respiratory/GI viruses

56
Q

Presentation of viral infection w/ no B cells

A

Enteroviral encephalitis, poliovirus

live vaccine contraindicated

57
Q

Presentation of viral infection w/ no granulocyte or complement

A

nothing special

58
Q

Presentation of fungi/parasites infection w/ no T cells

A

Candida, PCP

59
Q

Presentation of fungal/parasites infection w/ no B cells

A

GI giardiasis (no IgA)

60
Q

Presentation of fungi/parasites infection w/ no granulocyte

A

Candida, Aspergillus

61
Q

Epoetin alfa (erythropoietin)

A

Anemias (especially in renal failure)

62
Q

Thrombopoietin

A

Thrombocytopenia

63
Q

Oprelvekin (interleukin-11)

A

Thrombocytopenia

64
Q

Filgrastim (granulocyte colony-stimulating factor)

A

Recovery of bone marrow

65
Q

Sargramostim (granulocyte-macrophage colony- stimulating factor)

A

Recovery of bone marrow

66
Q

Aldesleukin (interleukin-2)

A

Renal cell carcinoma, metastatic melanoma

67
Q

IFN-α

A

Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

68
Q

IFN-β

A

Multiple sclerosis

69
Q

IFN-γ

A

Chronic granulomatous disease

70
Q

Therapeutic Ab for use in CLL . What is the Target?

A

Alemtuzumab

CD52

71
Q

Therapeutic Ab for use in Colorectal cancer, renal cell carcinoma. What is the Target?

A

Bevacizumab

VEGF

72
Q

Therapeutic Ab for use in Stage IV colorectal cancer, head and neck cancer. What is the Target?

A

Cetuximab

EGFR

73
Q

Therapeutic Ab for use in B-cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP. What is the Target?

A

Rituximab

CD20

74
Q

Therapeutic Ab for use in Breast cancer, gastric cancer. What is the Target?

A

Trastuzumab

HER2/neu

75
Q

Therapeutic Ab for use in IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis. What is the Target?

A

Infliximab, adalimumab

TNF-α

76
Q

Therapeutic Ab for use in Multiple sclerosis, Crohn disease. What is the Target?

A

Natalizumab

α4-integrin

77
Q

Therapeutic Ab for use in Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention. What is the Target?

A

Abciximab

Glycoprotein IIb/IIIa

78
Q

Therapeutic Ab for use in Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin). What is the Target?

A

Denosumab

RANKL

79
Q

Therapeutic Ab for use in Antidote for digoxin toxicity. What is the Target?

A

Digoxin immune Fab

Digoxin

80
Q

Therapeutic Ab for use in Allergic asthma; prevents IgE binding to FcεRI. What is the Target?

A

Omalizumab

IgE

81
Q

Therapeutic Ab for use in RSV prophylaxis for high-risk infants. What is the Target?

A

Palivizumab

RSV F protein

FA: random (15 decks)

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