Pharm Extra Flashcards
Does the sympathetic NS release ACh?
Yes.
Post-ganglionic fibers will release ACh onto sweat glands, causing the
secretion of sweat
Where are mAChR located?
CNS
Autonomic ganglia
Cardiac M
Smooth muscle
Sweat glands
Where are M2 receptors located
Heart
Smooth muscle
Nerves
Where are M3 receptors located?
Smooth muscle
Glands
Endothelium
Primary receptors on the heart?
B1–> increase rate of contraction (HR) and force of contraction
M2–> decrease HR, decrease strength of contraction and conduction velocity
Receptors in lungs
B2- bronchodilation
M2/M3- smooth muscle contraction
Histamine does what?
Decrease BP
Decrease PNS
Increase sympathetic NS
mAChR antagonist does what to smooth muscle?
RELAX
Increase in ___ means a increase in BP
Cardiac output
AChE Inhibitors have what effect on HR?
-binds to M2 receptors on SA and AV node,
Decreasing the HR
Cardiac glycosides do what strength of contraction and HR?
Increase the force of contraction (because we see an increase in Ca2+)
but decrease HR because we have a longer phase 3 (repolarization) because the NA/K pumps are inhibited.
Increase in force of contraction is a + ionotropic effect and increases diuresis, which decreases edema
Best drug for CHF?
Cardiac glycosides
B1 receptors increase the force of contraction (on ventricular myocutes) and increase the rate of contraction (on SA and AV node). What drug does the exact opposite?
M2 and M3
Decrease the rate of contraction (on SA and AV node)
Decrease the force of contraction
Decrease in BP
Decrease in parasympathetic
Increase in sympathetic. What effects do we see?
Decrease in renal flow causes the activation of renin–> retention of H20–> ______
Increase in HR (B1)
increase in force of contraction (B1)
Increase in preload
Increase in afterload
–> increase preload, afterload and increase EDEMA
What is the key thing to note about SM in the BV?
It does not have parasympathetic innervation.
ACh–> M3 receptors on endothelium–> release of NO–> vasodilate
