DSA: Autonomy Flashcards

1
Q

Describe a simple reflex arc involving skeletal muscle

A
  1. Afferent (sensory) stimulus detects unexpected stretch of a muscle
  2. Sends signal to muscle spindle located in the dorsal root ganglion of the spinal cord–> ventral root
  3. Synapse on alpha-motor neuron of stretched muscle
  4. FIRES
  5. Release ACh at the NMJ
  6. Causes contraction (shorterning of the stretched muscle
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2
Q

Did we use our brain for the reflex arch involving the skeletal muscle?

A

No.

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3
Q

In the autonomic NS, sensory information tells our body what?

A

When there is a change in our homeostasis.

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4
Q

Are we aware of the of the stimulus that activates our ANS?

A

No.

But ones that are, we do not control the responses.

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5
Q

What are sensory stimuli that can modify our ANS?

A

BP, PaO2, pH.

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6
Q

What controls the activation of somatic reflexes?

A

Any level of the CNS: but many of them are generated in the spinal cord.

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7
Q

What controls the activation of the ANS?

A

Lower levels of the brain: medulla–> hypothalamus.

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8
Q

Efferent (motor) neuron in the somatic reflex is made up of how many neurons?

A

1 alpha-motor neuron

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9
Q

Efferent (motor) neuron in the ANS is made up of how many neurons?

A

2: pre-ganglionic and post-ganglionic

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10
Q

How does your sympathetic NS respond to stimuli?

A
  1. Increase O2 to the “right” parts of the body by [increase HR and blood flow]
  2. Increase glucose;
  • [liver]–> glucose to the blood for use by skeletal muscles.
  • Other less important tissue will use FFA.
  1. We need to be able to clearly identify threats and responses
    - control focus and pupil (dilate)
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11
Q

How does your parasympthatetic NS respond to stimuli?

A
  1. Decrease O2 and decrease HR
  2. Sends blood to digestive tract
  3. Increase digestion
    - Glands in GI tract–> secrete enzymes/electrolytes
    - Increases instestinal motility
    - Relax sphincters so contents can from one part of the digestive tract to the other
  4. Store NRG
    - Liver–> store glucose; decrease ability to release
    - Adipose tissue–> store FFA
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12
Q

What are functions of the parasympathetic NS?

  • Pupils
  • Saliva production
  • HR
  • Bronchi
  • Digestive organs
  • Bladder-

Other?

A
  1. Constricts pupils
  2. Increase saliva production
  3. Decrease HR
  4. Constricts bronchi
  5. Stimulates digestive organs, pancreas, bladder
  6. Causes erection
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13
Q

What are functions of the sympathetic NS?

  • Pupils
  • Saliva production
  • HR
  • Bronchi
  • Digestive organs
  • Bladder-

Other?

A
  1. Dilates pupils
  2. Decreases saliva production
  3. Increases HR
  4. Dilates the bronchi
  5. Inhibits digestive organs, pancreas and gallbladder
  6. Relaxes bladder
    • adrenal medulla release of NE and EPI
  7. Stimulates orgasm
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14
Q

Describe the pathway of parasympathic NS and sympathetic NS

A
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15
Q

Post-ganglionic neurons in the sympathetic NS bind to what type of receptors?

A

Adrenergic

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16
Q

How are post-ganglioic cells different from pre-ganglionic cells?

A

Post-ganglioni cells have swellings called varisosities along the axon that allow the release of NT.

17
Q

Describe the synaptic cleft of post-ganglionic cells?

A

Larger, more open to the interstitial fluid because it does not make direct contact with the target organ. Thus, receptors for NT are distributed along the target organ

18
Q

What are the effects of the synaptic cleft of the post ganglionic cells being larger and more open? (3)

A
  1. NT have to travel further,
  2. More are detected in the blood
  3. Receptors can be activated by NT that are diffused from original point of release.
19
Q

What type of receptors are adrenergic?

A

Metabotropic (serpentine)– > thus they + 2nd messengers

20
Q

What type of receptors do post-ganglionic neurons in the parasympathetic NS bind to?

A

Muscarinic, which are metabotropic.

21
Q

Muscarinic Gi receptors

A

Found on heart

Binding causes -AC–> - cAMP production–> increase K+ efflux from nodal cells–> decrease HR

22
Q

Muscarinic Gq recetors

A

Found on glands

+IP3 and DAG–> release of Ca2+

23
Q

The synapse between a neuron that traveled through the sympathetic chain and synapsed on a chromaffin cell in the adrenal medulla.

A

Nicotenic cholinergic

24
Q

Alpha-1 receptor activation

A

Causes radial muscles to contract–> dilates the pupil

25
Q

Beta-2 activation

A

ciliary muscles relax–> [flattens lens]

26
Q

Beta-1 and Beta-2 activation

A

Increases HR and contraction

27
Q

Alpha-1 activation

A

Vasoconstriction–> increases BP

28
Q

Beta-2 activation

A

Bronchodilation

29
Q

Are SNS and PNS an off an off switch?

A

No. They work together and can work at the same time.

30
Q

Which receptor increases stroke volume and heart rate?

A

Beta 1 adrenergic

31
Q

Which receptors constrict smooth muscle, as a general rule?

A

Alpha adrenergic

32
Q

Which receptors increase glandular secretions in the lungs?

A

Beta adrenergic

33
Q

What regions of the heart are affected by beta 1 receptors?

A

AV / SA node

34
Q
A