Pharm - Exam 3 Flashcards
1
Q
- What is phase III?
A
Efficacy compared to standard of care
2
Q
- How do most chemo agents act?
A
Distrupt RNA
3
Q
- Target therapies?
A
Induce apoptosis
4
Q
- Differnce between Darbepoeitin & epoeitin?
A
Darbepoeitin has a longer 1/2 life than epoeitin.
5
Q
- What is the MOA for vinca alkaloids?
A
Prevent microtubule formation
6
Q
- When do taxanes work?
A
During S phase
7
Q
- Which drug are we most worried about extravastation (most potent)?
A
Vinca alkaloids
8
Q
- What are the monitoring paramaters for ESA’s?
A
Reticulocytes, serum iron, Hgb
9
Q
- what do you need to do 1st for Dextran injections?
A
Needs a test dose for anaphylaxis
10
Q
- Sickle cell crisis treatment of choice?
A
Hydration & pain management
11
Q
- What does hydroxyurea do?
A
Increases Hgb F
12
Q
- What are we measuring in animal tumor cell studies?
A
Efficacy
13
Q
- What is the advantage of non cell cycle-specific drugs?
A
Can attack tumor cells in G0 as well as other CELL CYCLE phases
14
Q
- What tumors are more sensitive to therapy?
A
Rapidly growing tumors because they have more cells that are actively dividing
15
Q
- Who is at risk for pulmonary depression on Bleomycin?
A
pt w/ supplemental O2 & pulm dz
16
Q
- what is used to prevent chronic, delayed cardiotoxicity
A
Cap anthracycline exposure
17
Q
- What is the mechanism of TKI resistance?
A
Change in AA sequence, decreases binding affinity
18
Q
- How long is the treatment for B12 deficiency?
A
Life long
19
Q
- What is the best treatment for B12 deficiency?
A
Oral cobalamin
20
Q
- What are the labs for Fe+deficiency anemia?
A
Low iron High transferrin Low transferring saturation Increased TIBC Microcytic
21
Q
- What is an ESA side effect?
A
Thromboembolism
22
Q
- What is a side effect of cytarabine?
A
Cerebellar toxicity
23
Q
- Which is an alkylating agent?
A
Cyclophosphamide
24
Q
- FA or B12 hgb response?
A
1-2 weeks
25
25. What is the definition of remission?
Unable to detect presence of cancer
26
26. Fe+ supplements?
All have different elemental iron but can all be used to treat iron deficiency
27
27. ESA’s should?
Decrease the need for RBC transfusion
28
28. What are Immunomodulators used to treat?
Multiple myeloma.
29
29. Leukovorin MOI?
Increases activity of 5FU
30
30. What is the MOA for Epipodophyllotoxins?
Inhibit DNA topoisomerase II
31
31. What is Aspiraginase used for?
Cancer that requires extracellular asparagine for survival
32
32. TKIs MOI
Prevent regular cell functions from occurring
33
33. What do monoclonal antibodies target?
Specific pathways (EGR, HER2, CD)
34
34. What is the advantage of having exposure to multiple drugs?
Wave—like -->to make sure most cells are destroyed in a constant fraction (log kill cell kinetics)
35
35. What ist the Gompertzian model?
Larger tumors have less dividing cells, less susceptible to chemotherapies.
36
36. What is the treatment regimen for AML?
7 + 3
37
37. Breast cancer is?
Hormonally sensitive
38
38. Breast cancer tx most important for choosing tx is?
Pre/postmenopausal status
39
39. What is the goal of skin cancer tx (melanoma)?
Prolong survival
40
40. What is the treatment for CML?
TKI---philadelphia chromosome
41
41. What is the definition of adjuvant chemotherapy?
After surgery to get undetected cancer cells
42
42. What is true of secondary malignancies?
Harder to tx than de novo cases.
43
43. Anthracyclines also?
Produce free radicals.
44
44. Chemotherapy?
Systemic therapy.
45
45. What is cobalamin nasal spray used for?
Maintenance for a patient that has responded to oral/IM therapy
46
46. Anemia presentation?
- Vertigo
- HA
- Dizziness
- Pallor
- Fatigue
47
47. Anemia risk factor?
Pregnant or lactating woman
48
48. What are three things that could reduce efficacy?
Pt specificcharacteristics (obesity, metabolism), mutations, decreased transport into cells, increased activity against drug there were three correct options
49
49. What can trigger a sickle cell crisis.
Dehydration
50
50. What is a complication of sickle cell crisis?
CVA
