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1. Exams - Semester 3 > Pharm - Exam 3 > Flashcards

Pharm - Exam 3 Flashcards

1
Q
  1. What is phase III?
A

Efficacy compared to standard of care

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2
Q
  1. How do most chemo agents act?
A

Distrupt RNA

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3
Q
  1. Target therapies?
A

Induce apoptosis

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4
Q
  1. Differnce between Darbepoeitin & epoeitin?
A

Darbepoeitin has a longer 1/2 life than epoeitin.

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5
Q
  1. What is the MOA for vinca alkaloids?
A

Prevent microtubule formation

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6
Q
  1. When do taxanes work?
A

During S phase

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7
Q
  1. Which drug are we most worried about extravastation (most potent)?
A

Vinca alkaloids

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8
Q
  1. What are the monitoring paramaters for ESA’s?
A

Reticulocytes, serum iron, Hgb

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9
Q
  1. what do you need to do 1st for Dextran injections?
A

Needs a test dose for anaphylaxis

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10
Q
  1. Sickle cell crisis treatment of choice?
A

Hydration & pain management

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11
Q
  1. What does hydroxyurea do?
A

Increases Hgb F

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12
Q
  1. What are we measuring in animal tumor cell studies?
A

Efficacy

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13
Q
  1. What is the advantage of non cell cycle-specific drugs?
A

Can attack tumor cells in G0 as well as other CELL CYCLE phases

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14
Q
  1. What tumors are more sensitive to therapy?
A

Rapidly growing tumors because they have more cells that are actively dividing

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15
Q
  1. Who is at risk for pulmonary depression on Bleomycin?
A

pt w/ supplemental O2 & pulm dz

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16
Q
  1. what is used to prevent chronic, delayed cardiotoxicity
A

Cap anthracycline exposure

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17
Q
  1. What is the mechanism of TKI resistance?
A

Change in AA sequence, decreases binding affinity

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18
Q
  1. How long is the treatment for B12 deficiency?
A

Life long

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19
Q
  1. What is the best treatment for B12 deficiency?
A

Oral cobalamin

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20
Q
  1. What are the labs for Fe+deficiency anemia?
A 
Low iron
High transferrin
Low transferring saturation
Increased TIBC
Microcytic
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21
Q
  1. What is an ESA side effect?
A

Thromboembolism

22
Q
  1. What is a side effect of cytarabine?
A

Cerebellar toxicity

23
Q
  1. Which is an alkylating agent?
A

Cyclophosphamide

24
Q
  1. FA or B12 hgb response?
A

1-2 weeks

25
Q
  1. What is the definition of remission?
A

Unable to detect presence of cancer

26
Q
  1. Fe+ supplements?
A

All have different elemental iron but can all be used to treat iron deficiency

27
Q
  1. ESA’s should?
A

Decrease the need for RBC transfusion

28
Q
  1. What are Immunomodulators used to treat?
A

Multiple myeloma.

29
Q
  1. Leukovorin MOI?
A

Increases activity of 5FU

30
Q
  1. What is the MOA for Epipodophyllotoxins?
A

Inhibit DNA topoisomerase II

31
Q
  1. What is Aspiraginase used for?
A

Cancer that requires extracellular asparagine for survival

32
Q
  1. TKIs MOI
A

Prevent regular cell functions from occurring

33
Q
  1. What do monoclonal antibodies target?
A

Specific pathways (EGR, HER2, CD)

34
Q
  1. What is the advantage of having exposure to multiple drugs?
A

Wave—like –>to make sure most cells are destroyed in a constant fraction (log kill cell kinetics)

35
Q
  1. What ist the Gompertzian model?
A

Larger tumors have less dividing cells, less susceptible to chemotherapies.

36
Q
  1. What is the treatment regimen for AML?
A

7 + 3

37
Q
  1. Breast cancer is?
A

Hormonally sensitive

38
Q
  1. Breast cancer tx most important for choosing tx is?
A

Pre/postmenopausal status

39
Q
  1. What is the goal of skin cancer tx (melanoma)?
A

Prolong survival

40
Q
  1. What is the treatment for CML?
A

TKI—philadelphia chromosome

41
Q
  1. What is the definition of adjuvant chemotherapy?
A

After surgery to get undetected cancer cells

42
Q
  1. What is true of secondary malignancies?
A

Harder to tx than de novo cases.

43
Q
  1. Anthracyclines also?
A

Produce free radicals.

44
Q
  1. Chemotherapy?
A

Systemic therapy.

45
Q
  1. What is cobalamin nasal spray used for?
A

Maintenance for a patient that has responded to oral/IM therapy

46
Q
  1. Anemia presentation?
A
  • Vertigo
  • HA
  • Dizziness
  • Pallor
  • Fatigue
47
Q
  1. Anemia risk factor?
A

Pregnant or lactating woman

48
Q
  1. What are three things that could reduce efficacy?
A

Pt specificcharacteristics (obesity, metabolism), mutations, decreased transport into cells, increased activity against drug  there were three correct options

49
Q
  1. What can trigger a sickle cell crisis.
A

Dehydration

50
Q
  1. What is a complication of sickle cell crisis?
A

CVA

1. Exams - Semester 3 (21 decks)

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