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1. Exams - Semester 3 > Pharm - Exam 1 > Flashcards

Pharm - Exam 1 Flashcards

1
Q
  1. What is the med that is indicated for the absence seizures only?
A

Ethosuximide

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2
Q
  1. Which drug has a side effect of weight loss?
A

Felbamate

Also : Ethosuximide, Topiramate, Zonisumide

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3
Q
  1. What drug does not cause diplopia?
A

Zonsiumide

Lacosamide, Lamotrigine, Phenytoin, Pregabalin, Tiagabine, Vigabatrin

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4
Q
  1. What are 2 drugs that are pan CYP inducers?
A

Phenobarb and CBZ

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5
Q
  1. What was false regarding gabapentin?
A

Not a pan inducer of hepatic enzymes

a. it is needed in high dose, is excreted unchanged, and has no known DIs

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6
Q
  1. How much active drug in phenytoin sodium?
A

0.92

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7
Q
  1. Calculate the loading dose
A

DL = (Vd)(Css)/(S)(F)

Vd = .65 x Wgt (Kg)

Css = 18!!!!

S (Sodium) Capsule & Injec = .92
S (Acid) Tablet & suspension = 1.0

F = 1

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8
Q
  1. Calculate the loading dose
A

(convert pounds to kg)

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9
Q
  1. What is the VPA dose range?
A

50-150

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10
Q
  1. What drug do you have to serum monitor?
A

Phenytoin (Also CBZ & VPA)

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11
Q
  1. What drug causes gingival hyperplasia?
A

Phenytoin

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12
Q
  1. What are the symptoms of acute intoxication of phenobarbitol?
A

Slurred speech,
Nystagmus,
Ataxia (unsteady gate)

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13
Q
  1. What is converted to phenobarb via hepatic oxidation?
A

Primidone

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14
Q
  1. What has to be tapered slowly to prevent rebound convulsions?
A

Phenobarb

Also Delirium

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15
Q
  1. Why do you have to start topirimate slowly?
A

Cognitive impairment

Used for migraines

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16
Q
  1. What’s not first line for early established stat epi?`
A

IV Valproate

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17
Q
  1. If you are on valproic acid and want to start lamotrigine why slowly?
A

SJS

Decrease Lamotragine by 50% if used in combo w/ VPA

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18
Q
  1. Typical first line for Parkinsons?
A

Rasagiline

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19
Q
  1. What is true about Diastat?
A

all of the above

  • Used for breakthrough seizures,
  • When on established AED,
  • Gel formulation w/ rectal admin,
  • Can’t give more than 5x a month
20
Q
  1. Which of the following drugs has significant drug interaction?
A

Valproic acid

NOT
Gabapentin
Levitiracetem
Pregabalin

21
Q
  1. Which drugs are used for general anesthesia in the treatment of stat epi?
A

Midazolam & Propofol

22
Q
  1. What is true?
A

All of the above

  • Lamotrigine level is inc during the placebo week,
  • CBZ interferes w estrogen and makes OCP ineffective,
  • Lamotrigine decreases the bioavailability of progesterone & makes OCP ineffective
23
Q
  1. What is true about Capylidene in the tx of Alzheimer’s?
A

Not 1st line

  • It is a medical food
  • Watch for risk of ketoacidosis
  • Increases triglyceride levels
24
Q
  1. Pt with a h/o Alzheimer’s now has aggression w no other Sx?
A

Anticonvulsants

25
Q
  1. Pt dx w new Alzheimer’s w h/o IBS, what should the initia tx be?
A

Donepezil

26
Q
  1. What drug causes memory loss?
A

NSAIDs

27
Q
  1. MOA of donepezil?
A

Ach inhibitor only

28
Q
  1. What cholinesterase inhibitor comes in a patch?
A

Rivastigmine

29
Q
  1. After 6 months what would the pts MMSE score would be if they started at 23?
A

24 (Inc 1-1.5)

30
Q
  1. Why do you use aspirin in the tx of AD?
A

Improve perfusion & helps w vascular dz

31
Q
  1. Alzheimer’s is now moderate, was on low dose donepezil, how should tx change?
A

Memantine

Donepezil in high doses can be used for moderate to severe but the dose is 23 mg – question option suggested increases

32
Q
  1. MOA of memantine?
A

NMDA antagonist

33
Q
  1. Young Parkinson’s patient preventing w/ tremors, what should initial tx be?
A

Amantadine

34
Q
  1. What do you add to CD/LD to extend?
A

COMT inhibitor (Entecapone)

35
Q
  1. 70 yo w/ not otherwise specified Parkinson’s?
A

CD/LD

36
Q
  1. Delayed on/no-on?
A

Add apomorphine plus trimethomenzamine

37
Q
  1. Clinical predictor of disease in PD?
A

Decrease response to dopamine

38
Q
  1. Who will most benefit from starting CD/LD initially?
A

Older pt w/ cog and functional impairment

39
Q
  1. What is the rationale for using Selegeline in tx of PD?
A

Delay need for LD by 9 months

40
Q
  1. ADR of amantadine?
A

Tachyphylaxis in 1- 2 months

41
Q
  1. MOA of Rotigotine?
A

Dopamine antagonist

42
Q
  1. Which of the dopamine agonists need to be renally dose adjusted?
A

Pramipexole

43
Q
  1. What class has the ADR brown-orange urine?
A

COMT inhibitor

44
Q
  1. What are the side effects of Galantamine?
A

N/V/D

45
Q
  1. What drugs don’t you give to pregnant people?
A

all of the above

Phenytoin, Valproic acid, Phenobarb

1. Exams - Semester 3 (21 decks)

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