Pharm - Exam 2 Flashcards
1
Q
- Hyperprolactinemia DA antagonism is due to what tract?
A
Infundibular
2
Q
- Sedative SE of TCA due to blocking of what receptors?
A
H1
3
Q
- Pt started on med has dry everything - aka anticholinergic SE - what drug did they most likely get?
A
Doxepin (TCA)
4
Q
- Difference between a FGA and an SGA?
A
SGA doesn’t cause TD
5
Q
- SGAs have what in common?
A
Block 5HT receptors
6
Q
- What would you need to monitor every 6 months when they start an antipsychotic?
A
AIMS
7
Q
- What would be the reason to start a pt on a LONG ACTING IM antipsych?
A
Non compliant pt
8
Q
- What would be a reason to start a pt on an IMMEDIATE ACTING IM antipsych?
A
Acute agitation
9
Q
- What drug would most likely cause pseudoparkinsonism?
A
Haldol (FGA), All other choices were SGAs
10
Q
- How would you tx acute dystonia?
A
IM benztropine
11
Q
- How would you tx akathisia?
A
PO Propranolol
12
Q
- How would you tx pseudoparkinsonism?
A
PO Benadryl
13
Q
- MOA of BZDs?
A
Enhance GABA activity
14
Q
- What would you want to monitor with clozapine?
A
Wt changes, WBC, ANC
15
Q
- Which agent do you have to take with meals?
A
Ziprasidone
16
Q
- Which drug causes GI distress, sex dysfxn & insomnia?
A
Citalopram
17
Q
- Which would not cause discontinuation syndrome?
A
Fluoxetine
18
Q
- Which of the follow doesn’t act on 5HT reuptake?
A
Buproprion
19
Q
- What would you have to do to start a pt on an MAOI who has been taking fluoxetine?
A
d/c fluoxetine & wait 5 wks to start MAOI
20
Q
- Whats the MOA of tranylcypromine?
A
MAO-I
21
Q
- Pt has hx of wgt gain & DM what would you NOT want to start them on?
A
Olanzapine
22
Q
- Pt has been on clozapine for 6 months and just recently had ataxia, seizure what mostly likely happened?
A
The pt stopped smoking 3 wks ago
23
Q
- Why are SSRIs (Sertraline) 1st line compared to TCAs (Imipramine)?
A
No fatality in overdose in SSRIs
24
Q
- Lady with classic MDD, what do we wanna give her?
A
Sertraline
25
1. Whats the MOA of duloxetine?
Mixed 5HT & NE reuptake inhibitor
26
26. Pt has a history of seizures what would we NOT want to give them?
Bupropion
27
27. What is true of buspirone?
Onset in 7-10 days
28
28. Which one would most likely cause hypersomnolence, tough time waking up, aka HANGOVER effect?
Diazepam
29
29. Best BZD for elderly?
Lorazepam
30
30. MOA of remelteon?
Melatonin agonist
31
31. MOA of suvorexiant?
Orexin antag
32
32. MOA of paroxetine?
SSRI
33
33. Remelteon what is it used for?
Falling asleep ONLY
34
34. MOA of diphenhydramine?
Anti-Histamine
35
35. What do you wanna tell everyone with a sleeping problem?
GET YOUR SLEEP HYGIENE
36
36. Why are benzos not 1st line for txing sleep/anxiety?
They get tolerance within 2 wks
37
37. What drug do you wanna give someone with hepatic dysfxn for mood ctrl?
Lithium
38
38. Lithium plus NSAID does what?
INCREASES the concentration of Lithium
39
39. Lithium plus caffeine does what?
DECREASES the conc of lithium
40
40. VPA plus CBZ does what?
Decreases the conc of VPA
41
41. What tract is basically tx of positive sxs?
Mesolimbic and mesocortical
42
42. Pt has BPD what do we wanna do to prevent a depressive episode?
Lamotrigine
43
43. Pt on lamotrigine what do we wanna monitor?
Rash
44
44. Pt on lamotrigine and gonna put them on VPA what do u have to do?
Decrease lamotrigine by 50%
45
45. Which one do u wanna give a pt who has a mixed manic episode?
VPA
46
46. When do you check the drug level of lithium?
Immediately before am dose (bc it’s a 8-10 hrs s/p dose trough level)
47
47. Which is a partial DA agonist?
Aripiprazole
48
48. VPA what do you wanna order?
Liver & VPA serum concentration
49
49. Pt has hypothyroidism what drug are they most likely on?
Lithium
50
50. Tyramine diet affects what drug?
Phenylzine
