Pharm Basics

Question 1

What kind of receptor is alpha1? Agonist?

Answer 1

Gq-> PLC-> IP3/DAG

Epi>NE

Question 2

What kind of receptor is alpha2?

Agonist?

Answer 2

Gi

Epi>NE

Question 3

What kind of receptor is Beta1?

Agonist?

Answer 3

Gs-> adenylyl cyclase-> cAMP-> Ca+

Iso> Epi=NE

Question 4

What kind of receptor is Beta2?

Agonist?

Answer 4

Gs ->cAMP

Iso>Epi>NE

Question 5

What receptors cause bronchial smooth muscle relaxation and decreased secretion?

Answer 5

Relaxation: B2
Secretion: A1

Question 6

What receptors cause glandular secretions?

Answer 6

M3

Question 7

As a general rule, what do Alpha1 receptors do?

Answer 7

Smooth muscle contraction, vasoconstriction

Question 8

As a general rule, what do Beta2 receptors do?

Answer 8

Smooth muscle relaxation, esp. bronchial/tracheal

Question 9

What effect does a mAChR antagonist have on the parasympathetic nervous system?

Answer 9

Decreases mAChR activity, so decreases parasympathetic activity

Question 10

What are the general effects of a Beta1 agonist?

Answer 10

Increased heart rate, increased contractility, and conduction velocity

Question 11

What are the general effects of cholinergic agonists?

Answer 11

Increased parasympathetic effects: miosis, bradycardia, lacrimation, salivation, increased GI secretion, bronchoconstriction

Question 12

What are the general effects of cholinergic antagonists?

Answer 12

Increased sympathetic effects: pupil dilation, HR acceleration, dry mouth, dry eye, urine retention