Movement Disorders Pharm

Question 1

What is the only drug for ALS?

Answer 1

Riluzole

Question 2

What are the drugs that help alleviate chorea in HD patients by impairing dopamine neurotransmission?

Answer 2

Reserpine and Tetrabenazine

Question 3

Drug of choice for Wilson Disease? MOA?

Answer 3

Penicillamine

Chelating agent for copper

Question 4

What dopamine agonist is injectable and can provide relief during “off” periods?

Answer 4

Apomorphine

Question 5

Dopamine receptor agonists? Serious side effects?

Answer 5

PBR- Pramipexole, Bromocriptine, Ropinirole

Side effects: nausea/vomiting, and hallucinations especially during withdrawl

Question 6

What PD drug is associated with livedo reticularis rash?

Answer 6

Amantadine- antiviral agent, unknown MOA

Question 7

What is the MAO-B inhibitor suffix?

Answer 7

-giline (selegiline, rasagiline)

Question 8

What is the COMT inhibitor suffix? Potential side effects?

Answer 8

-capone (tolcapone, entacapone) Tolcapone can cause acute hepatic failure

Question 9

What anticholinergic drugs (mAChR antagonists) are indicated in treating PD?

Answer 9

Benztropine, biperiden, orphenadrine, procyclidine, trihexyphenidyl

Question 10

What is the MOA of carbidopa?

Answer 10

DOPA decarboxylase inhibitor that does not cross BBB

Question 11

A resting tremor can be treated with what?

Answer 11

Beta blockers: metoprolol and propranolol