Pharm Flashcards
Which beta blocker is associated with dyslipidemia
Metoprolol
Hypertensive urgency vs emergency
Urgency is greater than/equal to 180/130 but without end organ damage.
Emergency there is evidence of damage
What is the name of an atypical antidepressant with antagonist effects at alpha-2 and other receptors? (Selective a2 blocker)
Mirtazapine
Which receptors does Scopolamine inhibit?
M1 muscarinic receptors, thus crosses the blood-brain-barrier
Where do benztropine and trihexyphenidyl act to reduce the tremors and rigidity in parkinsons patients
M1 muscarinic antagonists
MOA of Guanfacine?
Alpha 2 agonist, like clonidine, but more effective for tx of ADHD
What do Tolterodine and Oxybutynin do?
Affect the genitourinary system via inhibition of M3 muscarinic receptors
What are the two Beta Blockers contraindicated for HF, MI, Angina
Acebutolol, Pindolol due to partial B agonist activity
How does Beta-2 adrenergic activation cause decreased potassium?
Increased Na-K ATPase activity, ie increased insulin activity
What two drugs inhibit VMAT
Reserpine and Tetrabenazine
Which alpha 2 agonist is known to cause a direct coombs + test, and drug induced lupus
Alpha-methyldopa
Cocaine inhibits which two transporters?
Dopamine transporter (DAT), and Norepinephrine transporter (NET)
Which DUMBBELSS symptom is not alleviated by atropine in a patient poisoned by cholinesterase inhibitor?
Excitation of skeletal muscle and CNS because these effects are mediated by nicotinic receptors
Dobutamine has greater effect on beta 1 or beta 2?
Beta 1>Beta 2, alpha
Used for cardiac stress testing
Selective B1 antagonists: A-BEAM
Atenolol Betaxolol Esmolol Acebutolol Meteoprolol
Which drug is used as a cycloplegic/mydriatic eye examination drug, and also can prevent formation of adhesions in uveitis patients?
Homatropine—>muscarinic antagonist
Which selective alpha-1 antagonist is used to treat PTSD?
Prazosin
Where are D2 receptors found
CNS
In fat, stimulation of B3 receptors results in what effect on lipolysis? How?
Increased lipolysis
Gs activation, increased cAMP, activates PKA which phosphorylates hormone sensitive lipase
Which non-selective beta blocker can be used in tx of CHF?
Carvedilol
Which postganglionic sympathetic fibers release dopamine instead of norepinephrine?
Renal vasculature, renal smooth muscle
Which anti-muscarinic to treat extrapyramidal side effects of anti-psychotics
Benztropine
Does the adrenal medulla have postganglionic sympathetic fibers?
No; directly innervated by preganglionic sympathetic fibers
Which ache inhibitor is used as a long-acting tx for myasthenia gravis
Pyridostigmine
What are ipratropium and tiotropium? How do they work?
Inhaled antimuscarinics used in management of COPD because they antagonize M3 receptors, leading to bronchodilation and also decreased secretions
Name two antispasmodics used for IB-S that are muscarinic antagonists
Hyoscyamine
Dicyclomine
Trabecular outflow of aqueous humor can be increased by agonism of which receptor
M3 agonist
Which medication is given for autonomic insufficiency and postural hypotension?
The alpha 1 agonist Midodrine
What is the alpha-2 agonist Tizanidine used for?
Muscle relaxant; may be useful for treating spasticity associated w/ MS
What are the two beta blockers that are non-selective a1 and B antagonists?
Labetalol and carvedilol
Which anti-muscarinic, tiotropium or ipratropium is longer acting?
Tiotropium
What is the MOA of brimonidine and apraclonidine?
Alpha-2 adrenergic agonists used to treat chronic open angle glaucoma. Decrease aqueous humor production
What type of channels are Nicotnic Ach receptors?
Ligand gated Na/K (ion) channels
What is the receptor at the JGA that increases renin if stimulated
Beta-1
Competitive inhibitor at muscarinic receptors only, reverses both peripheral and central muscarinic toxicity.
Atropine
Pralidoxime is peripheral only, reverses the nicotinic effects of neuromuscular symptoms
Which do you give first, atropine or pralidoxime?
Atropine first, then pralidoxime due to risk of transient worsening of acetylcholiesterase inhibition
Which effect of epinephrine predominates at low dose
Beta agonist effect