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BCP 3 > Pharm > Flashcards

Pharm Flashcards

1
Q

Cyclophosphamide- Indications

A

Breast cancer, lymphoma and leukemia

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2
Q

Cyclophosphamide- MOA

A

Alkylating agent- nitrogen mustard representative drug, Cell cycle nonspecific- decreases DNA synthesis

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3
Q

Cyclophosphamide-AE

A

Hemorrhagic cystitis (Mesna to prevent), cardiotoxicity, myelosupression

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4
Q

Cisplatin- Indications

A

Solid tumors

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5
Q

Cisplatin- MOA

A

Alkylating agent. Non-specific. Platinum compound representative. Interferes with DNA inter strand crosslinks

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6
Q

Cisplatin- AE

A

Renal & ototoxicity, hypersensativity rxn, severe N/V

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7
Q

Methotrexate- Indications

A

ALL, breast, head & neck, Non-hodgkin, osteo.

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8
Q

Methotrexate- MOA

A

Antimetabolite- Folate antagonist- cell cycle specific. Binds to enzymes blocking DNA synthesis, repair and cellular replication

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9
Q

Methotrexate- AE

A

Kidney injury, mucositis, elevated LFTs, rash. Interactions with NSAID, penicillin, PPI

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10
Q

Fluorouracil- Indications

A

Breast, colon & gastric CA

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11
Q

Fluorouracil- MOA

A

Antimetabolite- cell cycle specific- pyrmidine analogue- Interferes with DNA & RNA synthesis due to lack of thymidine

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12
Q

Fluorouracil- AE

A

stomatitis, GI ulcer, Hand & foot syndrome, cardiotoxicity-angina

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13
Q

Anastrazole- MOA

A

Aromatase inhibitor- Hormonal agent- Non-specific- interferes with estradiol production in peripheral tissues- inhibits conversion of adrenally generated androstenedione

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14
Q

Anastrazole- Indications

A

Post menopausal breast cancer

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15
Q

Anastrazole- AE

A

Cardiovascular, flushing, metabolic disturbances

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16
Q

Vincristine- Indications

A

ALL, CNS tumors, Hodgkin, NHL

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17
Q

Vincristine- MOA

A

Vinca alkyloid- cell cycle specific- antimicrotubule- Binds to tubulin inhibiting microtubule formation- cell arrested at metaphase

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18
Q

Vincristine- AE

A

Constipation, neurotoxicity, cranial nerve disorder, phlebitis & cellulits. Death with intrathecal admin!

19
Q

Paclitaxel- MOA

A

Antimicrotubule- cell cycle specific- G2/ M phase- Bind to tubulin leading to nonfunctional microtubles- chromosome desegregation does not occur

20
Q

Paclitaxel- AE

A

Neutropenia, peripheral neuropathy, bradycardia

21
Q

Irinotecan- Indications

A

Colon & rectal carcinoma

22
Q

Irinotecan- MOA

A

Topoisomerase 1 inhibitor- cell cycle specific- prevents religation of single strand DNA breaks

23
Q

Irinotecan- AE

A

myelosupression, neutropenia, diarrhea

24
Q

Imatanib- Indications

A

CML, GI stromal tumors

25
Q

Imatanib- MOA

A

Targeted therapy. Inhibits tyrosine kinase- blocks proliferation, platelet growth factor, stem cell growth factor, induces apoptosis.

26
Q

Imatanib- AE

A

Edema, fluid retention, hepatotoxicity, thrombocytopenia, neutropenia

27
Q

Doxorubicin- Indications

A

Breast, metastatic, leukemia & lymphoma

28
Q

Doxorubicin- MOA

A

Anthracycline- cell cycle specific- Inhibits topoisomerase II, iron chelator binds to cell membrane and produces free radicals to cleave DNA.

29
Q

Doxorubicin- AE

A

Cardiotoxicity, secondary malignancies (heme), extravasation, hepatic fxn

30
Q

Etoposide- MOA

A

Topoisomerase II inhibitor, binds to topo II and causes DNA strand cell break. Cell cycle specific

31
Q

Etoposide- AE

A

Inflamed mucous membranes, secondary malignancies, hepatotoxicity, diarrhea

32
Q

Paclitaxel- MOA

A

Antimicrotubule/ mitotic inhibitor, cell cycle specific, prevents chromosome separation

33
Q

Paclitaxel- AE

A

Neutropenia, peripheral neuropathy, bradycardia

34
Q

Tamoxifen- Indications

A

Breast CA

35
Q

Tamoxifen- MOA

A

Hormone therapy, cell cycle non-specific- Non steroidal anti-estrogen, Binds to estrogen receptor to prevent growth. Only works on estrogen receptor positive

36
Q

Tamoxifen- AE

A

Flushing, thromboembolic events, uterine CA

37
Q

Leuprolide- Indications

A

Prostate & brest CA

38
Q

Leuprolide- MOA

A

Hormal therapy, cell cycle non-specific. Inhibit gonadatropin secretion or action- surpasses effects of steroid genesis due to decreased LSH, FSH.

39
Q

Bevacizumab- Indications

A

Antiangiogenesis- cuts off blood supply to tumors. Metastatic colorectal CA

40
Q

Bevacizumab- MOA

A

Monoclonal antibody, immunotherapy- cell cycle nonspecific. Attaches to vascular endothelial GF- blocks stimulation of new blood vessels

41
Q

Bevacizumab- AE

A

HTN, stomatitis, blood, protein in urine, GI bleed, bowel perforation, stroke

42
Q

Interferon alpha- Indications

A

Hematologic & solid tumors

43
Q

Interferon alpha- MOA

A

Biologic response modifier- immunotherapy- suppress cell proliferation, activate macrophages, increased cytotoxicity of lymphocytes

44
Q

Interferon alpha- AE

A

Flu like symptoms, N/V/D, skin rash, bleeding, hypotension

BCP 3 (10 decks)

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