Pharm 3 Flashcards
CI benzos vs big AE; CI; tx barb vs CI sodium bicarb
glaucoma, <6mo, MG, sleep apnea vs blisters; liver impair, resp dz; tx the pt not the lvl -> taper, supportive vs hypoCl, hyperNa
how to tx opioid tox vs opioid w/drawal. CI opioids in general?
supportive, naloxone vs methadone, buprenorphine +/- naloxone, clonidine, chlorpromazine if emesis, lofexidine, CBT. other opiates, resp/CNS dep, GI obstruction/ileus
bupropion vs varenicline for NRT
DNRI; AE tach, wt loss, liver dysfxn, psych exac; CI MAOI, eating d/o, h/o sz vs a2B2 nic Ach ag; AE GI, nightmares; CI caution in mental health -> need psych f/u, BBW suicide
what are 1st lines (3) SGA for schizo & what else can they tx? clozapine treats?
risperidone -> bipolar I, autism; aripiprazole -> bipolar, maj dep, Tourette; ziprasidone -> bipolar, acute agit but highest risk for QTc prolong. refractory schizo
EtOH MOA vs its 4 stages
NMDA antag, inc GABA -> DA in nucleus accumbens vs tremor, insomnia, agit/anxiety, hangover -> tactile halluc -> tonic clonic sz -> delirium tenens
AE disulfiram vs naltrexone vs acamprosate
liver fail, optic neuritis; for >12hr EtOH vs opioid w/drawal, abd cramps, insomnia, heptox vs CV, suicidal; for maintenance
how to tx lithium tox? considerations for mood stabilizers?
dc, gastric lavage, hemodialysis if >4meq acute or >2.5meq chronic. screen for preg, serum drug lvls for Li/val/carbam
pharmacokinetics vs CI vs DI for SSRI (CI = same for SNRI)?
lipophilic, food inc sertraline absorption, fluoxetine has longest 1/2 life vs MAOI, linezolid, IV methylene blue vs antiPLT/Coag
CI TCA. TCA OD sxs & tx?
MAOI, -triptyline no cisapride b/c QTc. Convulsion, coma, cardiotox. supportive, AC, bicarb
vilazodone vs vortioxetine/Trintellix
SSRI + 5HT1A partial ag, higher nausea & diarrhea, CI linezolid/blue/MAOI vs SSRI + 5HT1A partial ag & 5HT3/7 antag, nausea & abnl dreams, same CI
esketamine indic & MOA vs AE vs CI vs BBW
resistant dep, C-III NMDA antag -> inc gluE vs dysgeusia/nausea, CNS dep, dissoc vs intracerebral hem, AV malform, aneurysm vs abuse, CNS dep, dissoc
brexanolone indic & MOA vs AE vs PK vs BBW
PPD, C-IV pos GABA-A receptor modulator vs HA, dizzy, sedation vs 60hr infusion vs excess sedation & LOC
buspirone indic & MOA vs AE vs CI vs DI
2nd in line for GAD (if no BZD), partial ag presynaptic 5HT1A vs HA, dizzy, nausea vs MAOI vs sero syndrome
narcolepsy meds: ar/modafinil vs sodium oxybate vs pitolisant
stim hypocretin neurons or DNRI -> inc DA in nucleus accumbens vs change patterns to nml sleep by inc inhib vs H3 antag
cocaine w/drawal sxs vs washout syndrome
hyperPRL, cravings, brady, diarrhea, psychosis vs catechol depleted -> CNS dep, brady/HOTN; tx w/ bromocriptine, amantadine, bupropion
