Hem/Onc 2

Question 1

Amyloidosis vs Waldenstrom

Answer 1

HOTN, macroglossia, nephrotic proteinuria, acquired Factor X defic vs inc igM; hyperviscosity syndrome - blurry, CHF, AMS, mucosal bleed; bone marrow shows lumphoplasmacytic infiltrates

Question 2

Ddx: solitary plasmacytoma vs plasma cell leukemia vs POEMS

Answer 2

Bone lesions but nml bone marrow vs yep vs polyneuropathy, organomegaly, endo, monoclonal protein, skin change

Question 3

Features vs tx of hairy cell leukemia. LGLL?

Answer 3

Fried egg, no CD5/hypermutation IGHV/BRAF V600E, splenomegaly vs nucleoside analogs cladribine, pentostatin; ritux. CD8, autoimmune/RA, neutropenia vs observe, Abx, RA consult, transfusion, splenectomy, MTX, alem-mab against CD52

Question 4

Essential thrombocytopenia

Answer 4

Vasomotor, a/v thrombosis, Sab, burning palm/soles, acrocyanosis vs inc PLT/megakaroocytes, no fib/dysplasia vs CVD (2), anagrelide, PLT aphresis

Question 5

PMF

Answer 5

Bone pain, hyperuricemia, big spleen syndrome vs dry aspirate, silver/reticulin show fib, PDGF stim fibrocytes vs palliative/supportive

Question 6

SO11 = marker for what? What to chk before ritux?

Answer 6

Indolent mantle cell lymphoma. HBV

Question 7

Examples of primary vs secondary lymphedema

Answer 7

Congen like Milroy, praecox like Meige, tarda vs infxn, malig, trauma, excision, obstruction/interruption, rads

Question 8

CLL vs SLL vs monoclonal B lymphocytosis

Answer 8

> 5x10^9 B cells in peripheral blood vs LN vs < that of CML