Hem/Onc Flashcards

1
Q

Biphasic Bartonella. Carrion dz vs dx vs tx

A

Infect RBC then endothelial cells. Oriya fever w/ anemia then verruga peruana w/ angioprolif vs presentation vs amox/clav, cipro

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2
Q

Pertactin in Bordetella. Dx?

A

Bind heparin sulfate on glycoproteins and CR3. Presentation & cx

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3
Q

Dx vs tx ana/Ehr. Bacteriology?

A

Clinical + PCR vs doxy. Weak gram stain; Obligate intracellilar -> no lysosome fusion -> lysis of morula -> more infxn

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4
Q

Dx w/ ELISA for proteins or ag, PCR viral genome. Tx by watch or chemo

A

HTLV1/ATL

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5
Q

Biphasic fever, leukopenia, rash but not on palms/soles. Dx by immunofluorescence. Tx supportive

A

Colorado tick fever

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6
Q

Conjunctivitis, low grade fever, maculopapular rash; dx urine/serum RNA NAAT or sero igM; tx supportive but inc Guillain Barre

A

Zika

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7
Q

Blood smear = good standard; can chk ring trophozoites or crescent gametocytes

A

Malaria

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8
Q

Iron absorbed in where? What 3 meds blocks absorption? What specially inc vs Dec absorption?

A

Duo/upper jeju. Phytares, antacids, tannins. Gastric acid vs iron overload

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9
Q

Inc MCV but no anemia means? Meds causing macrocytosis? What part of B12 pathways causes hereditary megalo anemia vs abnl myelin?

A

Alc, liver dz/cirrhosis -> acetald -> acantho/sour cells. MTX, hydroxyurea, AZA/6MP, cap/cladribine, chemo, RA pts. Abnl cubulin vs no met aa

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10
Q

Splenectomy concerns:

A

Encaps from H flu, S pneu, N men -> 3 vax; PCN x2y post splenectomy, prompt care after animal bite, malaria prophylaxis for travel; inc CVD risk

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11
Q

Hydros fetalis

A

Mom O blood, baby A/B blood; mom Rh-, baby Rh+ -> baby anemia/hemolysis, jaundice, hypoglycemia -> pos Coombs & retic count -> RBC transfusion, phototherapy, IVIG

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12
Q

When to do rapid ELISA & fxnal assay? How to tx typical vs atypical HUS?

A

Heparin induced thrombocytopenia. IV fluids/electrolytes, dialysis vs plasmapheresis, ecluzimab

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13
Q

What’s the underlying cause: mucous bleed, immediate surg bleed, petechiae, small superficial bruise vs soft tissue bleed/hemarthroses, delayed surg bleed, deeper bruise

A

Primary vs secondary hemostasis issue

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14
Q

Liver dz: you clot and bleed simult, tx?

A

Tx underlying, FFP replacement factors, cryoprecipitate

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15
Q

When do you need RBC vs plasma transfusion? When to cryoprecipitate? Which blood component most likely cause bacterial sepsis?

A

Hb<7 vs massive transfusion, warfarin reversal, TTP. Fibrinogen <100, DIC, liver fail, intracranial hem post tPA. PLT

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