Pharm

Question 1

fxn of ovaries (3). fxn of estrogen (7) vs progesterone (7)

Answer 1

follicular maturation; release E, P, testosterone. endometrium prolif, FSH differentiation on granulosa, ductal epith growth by inc mammary progest receptors, inc lipoprotein receptors -> inc HDL/dec LDL & chol, inc bone maturation/dec osteoclast, dec fibrinogen & antithrombin III vs prep/maintain preg, oocyte, implant, dec myometrial ctx, inhib PG, stim mammary gland, antagonize estrogen & PRL

Question 2

can you use emergency contraception in BF?

Answer 2

yes

Question 3

how does estrogen in ocp suppress preg? DI for ocp?

Answer 3

dec FSH -> no dominant follicle. 3A4 inducers (steroids, antiepileptics), HIV/hep C protease inhibitors, tranexamic acid, abx, prednisone

Question 4

which type of ocp is recommended for BF?

Answer 4

progestin only pill

Question 5

DHEA/androstenedione -> testosterone -> DHT, estradiol. testosterone bound to SHBG inc vs dec by?

Answer 5

estrogen, TH, active liver cirrhosis vs androgen, GH, obesity

Question 6

7 therapeutic uses for androgens. AE for androgen/testosterone replacement therapy?

Answer 6

hypogonad/pit, gyn (endometriosis, PMP, brca chemo, dec pp br engorge), reverse protein loss, anemia, osteoporosis, growth stimulator in delayed puberty, transex. HTN, gynecomastia, polycythemia, LDL changes, liver tox

Question 7

list 4 main anti-androgen meds and necessary indic

Answer 7

GnRH antag, GnRH ag, 5a-reductase inhibitors, androgen receptor antag (for advanced prca, can be used w/ GnRH ag)

Question 8

AE vs CI of PDE5-I. what else is PDE5-I approved for?

Answer 8

color disturbance, flushing, HA, HoTN vs organic nitrates, alpha blockers. pulm arterial HTN

Question 9

alprostadil MOA vs AE

Answer 9

PGE1 -> AC -> cAMP -> blood flow vs priapism, pain, syncope, systemic. do trimix -> combo of alprostadil, phentolamine, papaverine

Question 10

list 5 unapproved drugs for ED

Answer 10

trazodone, yohimbine, phentolamine, papaverine, apomorphine

Question 11

complicated gonorrhea tx: preg vs disseminated vs conjunctivitis vs neonatal

Answer 11

same as nonpreg vs IM/V ceftriaxone 24h, 48h, 7d PO vs ceftriaxone + lavage vs AgNO3/tetra/emycin or IM/V ceftriaxone

Question 12

how to tx chlamydia in preg vs peds

Answer 12

emycin, amox vs ophth or <45kg -> emycin, >45kg -> azith, >8yo -> azith or doxy

Question 13

LGV vs granulosum inguinale/Donovanosis

Answer 13

painful buboes, LAD; tx w/ doxy or erythro vs painless ulcers, subq granuloma, beefy red; tx w/ azith, doxy, cipro, emycin

Question 14

list meds & procedures for HPV. know their MOA & AE

Answer 14

imiquimod, podofilox, sinecatechins; cryo, tri/bichloroacetic acid, surg

Question 15

MOA vs AE fluconazole. MOA vs AE vs note about ivermectin

Answer 15

inhib ergosterol & 3A4 vs hepatotox, QTc, sz, cat D in preg. bind to gluE-Cl channels -> hyperpol vs urticaria, DI w/ warfarin vs cat C in preg, rpt dose in 2wks for scabies

Question 16

MOA vs AE vs CI lindane vs malathion

Answer 16

GABA antag vs pruritus, dizzy, myelosuppress, sz, neurotox vs infants, epileptics, Norwegian/crusted scabies, preg cat C. organophosphate -> cholinesterase inhibitor vs irrit, chem burn vs infants, flammable

Question 17

addyi vs vyleesi

Answer 17

sero 1A ag/2A antag. AE HOTN, syncope esp w/ EtOH, CNS depression vs MC1/4R agonist. AE HTN -> limit 1 dose/24h or 8 dose/mo

Question 18

7 meds CI for BF

Answer 18

antineo, amphetamines, nicotine, immunosuppress, ergot, lithium, abusive drugs

Question 19

CI for rhGH

Answer 19

malig, acute critical illness, obesity/Prader Willi w/ airway obstruction, DM retinopathy, closed epiphyses