Path 2 Flashcards
autoimmune ECM1, HLARQ7-9; superficial hyperkeratosis, no rete ridges, hydropic basal cells; fusion of labias, clit, introitus scar. sl inc risk of vulvar SCC
lichen sclerosus
emotional/itch -> leathery thickened skin, sq cell hyperplasia w/ no atypia
lichen simplex chronicus
MRSA, E coli, peptostrep + bacteroides cause this
vulvar abscess
bartholin cyst/abscess caused by?
gonorrhea, E coli + bacteroides
Papillary hidadrenoma
from HPV; red nodule in inter/labia w/ double layered epith: top = columnar glandular epith pos for CK7, bottom = flat myoepith cells pos for actin
eczema-like scaly sl raised red edges in vulvar area, from apocrine glands -> mucus-producing neoplastic cells
vulvar extramammary Paget
vulvar or vag (ant distal third) melanoma mets by?
can mets via hematogenous
know 3 types of vulvar SCC
basaloid, warty; keratinizing
ovarian stromal hyperplasia vs ovarian hyperthecosis
prolif stromal cells w/ scant cyto w/o luteinization vs prolif stromal cells w/ abundant cyto w/ luteinization. both produce excess androgen
GCT: dysgerminoma vs yolk sac tumor vs chorioca
isochrom12p, KIT; lg undifferentiated germ cells w/ glycogen rich cyto & thin fibrous septa vs primitive epith cells w/ glycogen rich cyto; schiller-duval bodies vs cytiotropho -> mononucleated, clear cyto; syncytiotropho -> hyperechromatic nucli, baso cyto
which GCT has high LDH & BHCG w/ fried egg appearance?
dysgerminoma & seminoma
sertoli vs leydig vs granulosa tumors
male sex stromal tumors: hormonally silent or estrogen, no atypia, fibrous stroma vs Reinke rhomboid inclusions, testosterone or estrogen, yellow/tan, lots eos cyto vs Call/Exner bodies, coffee bean sign, lightly eos cyto, juvenile & adult type
HPV 16/18, verrucous papules w/ hyperkeratosis, koilo, acanthosis, melanin pig
bowenoid papulosis
4 forms of HGPIN. This is a precursor to? What else is over-expressed in PAC?
Tuft, micropapillary, cribriform, flat. PAC. AMACR mito and peroxisome enzyme
Primary intraepothelial & secondary epidermoidtropic; eczema, mucin secreting; pos for PAS, alcian blue, mucicarmine
Vulvar extra mammary Paget
Pelvic vs extra pelvic endometriosis. Immuno chem for endometriosis
Superficial peritoneal: serosa, blue/black powder lesion; ovarian endometrioma: chocolate cyst; deep infiltrating: rectal, sigmoid vs upper abd or diaphragm -> hemoptysis, hematochezia, hematuria. CK 7/18, E/P (colon ca is CK20 pos)
Type I vs II endometrial carcinoma
Estrogen sensitive. PTEN, MMR, MSH1/2/6, ARID1A, POLE vs not estrogen sensitive; grade 3 endometrial ca, clear cell ca, serous ca, carinosarcoma; all ER/PR neg. PPP2R1A
