Pharm 1 Flashcards
amide LA
any of the i-caines. metabolized in liver
esther LA
procaine, tetracaine, cocaine. metabolized in plasma cholinesterases. procaine still has a slight amount in liver (maybe they all do?)
prilocaine adverse reaction
metheoglobinemia
LA general adverse reaction
cardiovascular collapse (myocardial depression), hypotensive shock
LA moa
blocks sodium from entering neuron
absorbtion of LA
only free base (non ionized) can be transported across neural membrane (then only ionized form is effective). inflamed tissue has lower than normal pH making it more ionized and less effective
2% lidocaine has
20mg/ 1 mL solution
propranalol and LA
increases effect of lidocaine- slows down heart by beta blocker (less delivery to liver), also competes for same enzyme once in liver
toxic reaction to LA
depends on blood levels mostly. cause depression of inhibition of CNS neurons- but first see CNS excitation.(first sign).
LA and veins
are a vasodilators (except cocaine)
1:100k epi is
.01 mg epi per 1 mL
epi and heart disease
.04 mg is hieght of what AHA recommends
pennicillin G
more senesitive to acid degradation than oenicillin (injected not take orally)
best gram neg pen
ampicillin
not cross allergic with pen
cephalosporins and ampicillins are. erythromycin is not
