pharamacodynamics summary

Question 1

describe the difference between affinity, efficacy, and potency of agonist

Answer 1

• affinity refers to the strength of the binding between agonist and receptor
• efficacy- the ability of the agonist to activate the receptor and produce a response
• potency - the concerntrattion of an agonist required to produce specific effect

Question 2

explain the difference between full, partial and inverse agonist

Answer 2

• full = activate the receptor fully and produce a maximal response
• partial = activate the receptor and produce a submaximal response
• inverse agonist = bind to the inactivate state of the receptor and reduce the constitutive activity

Question 3

explains the general classes of anatagonism

Answer 3

• competitive = competes with the agonist to bind to the receptor
• irreversible = irreversibly binds to the receptor so that the agonist can not bind

Question 4

define the effect of competitive and irreversible competitive on the agonist dose response curve

Answer 4

• competitive antagonism shifts it to the right without affecting the maximal respsinse
• irreversible = reduces the maximal respsinse of the agonist

Question 5

how is the schild plot and equation used to quantify antagonism

Answer 5

• the school equation is used to determine the anatagonistbptency and affinity
• the schilds plot is a graphical representation of the equation which allows the determination of the antagonists PA2 value