drug interactions

Question 1

what is a drug interaction

Answer 1

the effect of one drug are changes by the presences of another drug , herbal medications, food, drink, or by environmental changes

Question 2

what are the types of drug interactions

Answer 2

• pharmacokinetics- what the key does with the drug - changes in plasma conc (ADME)
• pharmacodynamics- what the drug does to the body - changes in the drug response at site

Question 3

what are the factors that increase chance of drug interaction

Answer 3

• small therapeutic window
• careful dose control
• elderly - poly pharmacy \
• impaired liver or renal

Question 4

absorption interactions

Answer 4

• altered ph
• formation of drug chelates
• altered git motility
• inhibition or induction of drug transport proteins

separate the doses

Question 5

distribution interactions

Answer 5

• protein binding, induction or inhibition of drug transport proteins
• highly bound drugs can displace others and increase the amount of free drug and the overdose

Question 6

metabolism interactions

Answer 6

• changes in first pass metabolism, changes in enzyme activity ( inhibition and induction)
• enzyme induction increase enzyme activity and metabolism of drug
• enzyme inhibitors decrease tge enzyme activity and metabolism of drug

Question 7

what are the enzyme inducers CRAP GPS

Answer 7

• carbamazepine
• rifampacin
• alcohol (chronic amount)
• phenyton
• grisefulvin
• phenobarbiton
• smoking

Question 8

what are the enzymes inhibitors SICK FACES. COM

Answer 8

s = sodium valproate
i = isoniazid
c = cimetidine
k = ketoconazole

f = fluconazole
a = alcohol ( acute amount)
c = chloramphenicol
e = erythromycin
s = sulphonamides
.
c = ciprofloxacin
o = omeprazole
m = metronidazole

Question 9

when does alcohol act as an