Ph Of Amino Acids

Question 1

What is a buffer?

Answer 1

Solution that can resist changes in ph when acid or base is added

Question 2

What is an effective buffer constant?

Answer 2

Ph = PKA +\minus 1

Question 3

In low ph alanine is

Answer 3

Both cooh and nh3 groups are protonised

Question 4

What neutral ph alanine is

Answer 4

Has a net change of 0. Form 2. The cooh group dissociates to COO forming zwitterions.

Question 5

At a higher ph alanine is

Answer 5

. Only the nh3 group is ionized to nh2 gp.

Question 6

Pl for alanine is

Answer 6

Pl= pk1 + pk2 \2

Question 7

How many ionizable forms does histidine have?

Answer 7

3

Question 8

What are they and there net charge

Answer 8

COOH (2+) , NH+ ( +1) , NH3+ ( 0)

Question 9

If Ph is more acid that pI, protein will have a net

Answer 9

Positive charge

Question 10

If ph is more basic than Pi, protein will be

Answer 10

Negative charge

Question 11

Does uncharged drugs pass the intestinal lumen more readily or less readily?

Answer 11

More readily

Question 12

An increase in Hco3 causes

Answer 12

Ph to rise

Question 13

How is respiratory acidosis formed?

Answer 13

By pulmonary obstruction, leading to increase in carbon dioxide, causing a drop in ph.

Question 14

Wat is the enzyme that catalyses co2 to h20. To form bicarbonate

Answer 14

Carbonic anhydrase

Question 15

Formula for conversion

Answer 15

Ph= 6.1 + log (HCO3)/0.03 * pco2

Question 16

What is the normal range of blood buffers in an adult?

Answer 16

7.40 +\minus 5

Question 17

When is acidosis diagnosed?

Answer 17

When the ph is less than 7.35

Question 18

When is alkalosis diagnosed?

Answer 18

When the ph is greater than 7.45

Question 19

What is the normal Pco2?

Answer 19

40 mmHG

Question 20

What is the normal HCO3?

Answer 20

24 mM

Question 21

Approx how much of our body is water?

Answer 21

60 percent

Question 22

How and where is water distributed?

Answer 22

Intracellular and extracellular

Question 23

Why does water form hydrogen bonds?

Answer 23

It’s a dipole molecule with an uneven distribution of electrons between the hydrogen and the oxygen atoms.

Question 24

How much acid is produced in a day?

Answer 24

22 000

Question 25

Where and what is the widest ph range achieved?

Answer 25

In the liver, heart and nerve conduction. The ph is 6.8 to 7,8

Question 26

How is excess acid excreted in the body?

Answer 26

Exhaled as co2 or excreted in the urine.

Question 27

What is ph?

Answer 27

Negative log of its hydrogen ions concentration

Question 28

What is Ka?

Answer 28

Dissociation constant

Question 29

Henderson- Hasselbalch equation defines

Answer 29

The relationship between the pH of a solution, the Ka of the acid and the extent of acid dissociation.

Question 30

Bicarbonate carbonic acid is a major buffer and where is it found?

Answer 30

Rbc and extracellular fluid

Question 31

Hemoglobin is a major buffer and where is it found?

Answer 31

Rbc

Question 32

Phosphate buffer is a major buffer and where is it found?

Answer 32

Urine and most cells

Question 33

Protein buffers is a major buffer and where is it found?

Answer 33

Plasma and cells

Question 34

NH3 and Nh4+ is a major buffer and where is it found?

Answer 34

Urine

Question 35

What does normal metabolic generates?

Answer 35

Metabolic acids
Inorganic acids
Carbon dioxide.

Question 36

Carbon dioxide reacts with water to form

Answer 36

Carbonic acid which dissociates to form bicarbonate and a porton

Question 37

Carbonic acid is a weak acid and it is made in the

Answer 37

TCA CYCLE

Question 38

Where is acetoacetic acid and beta hydroxybutyrix acid sources from?

Answer 38

Fatty acid beta oxidation to ketone bodies

Question 39

Acetic acid sources are from

Answer 39

Ethanol metabolism

Question 40

Dehydrogenase phosphate

Answer 40

Dietary organic phosphate