pH, acids and bases Flashcards

week 2

1
Q

define pH

A

-log10[H+]

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2
Q

define acidosis

A

pH is less than 7.35

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3
Q

define alkalosis

A

pH is more than 7.45

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4
Q

what is the normal range for physiological pH in the body?

A

7.35 - 7.45

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5
Q

define acid

A

molecules that tend to release protons

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6
Q

define base

A

molecules that accept protons

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7
Q

an acid is a proton …

A

donor

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8
Q

a base is a proton …

A

acceptor

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9
Q

define conjugate base

A

chemical formed upon ionisation of an acid

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10
Q

define conjugate acid

A

acid formed when a base and proton binds

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11
Q

the larger Ka is, the … the acid

A

stronger

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12
Q

the smaller pKa is, the … the acid

A

stronger

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13
Q

define pKa

A

the pH at which the acid is half dissociated into H+ and A-

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14
Q

define buffer

A

a substance that resists pH change on addition of acid or base

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15
Q

when do acids or bases act as buffers?

A

when the pH is close to their pKa (+/- 1 pH unit)

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16
Q

define buffering region

A

when there is roughly equal amounts of acid and base

17
Q

what are the requirements of a buffer?

A

their pKa value must be close to the pH needed
must be biologically and chemically inert

18
Q

what ions buffer blood?

A

phosphate (HPO42-) and bicarbonate (HCO3-)

19
Q

define compensatory respiratory alkalosis

A

excess CO2 exhaled at the lungs to increase pH/reduce acidity

20
Q

explain the importance of physiological buffers
examples

A

prevent large changes in the pH of bodily fluid
eg. phosphate and bicarbonate

21
Q

define dissociation

A

loss of H+ ions