PG

Question 1

ABCB1 is a

Answer 1

p-gp

Question 2

how C-T 3435 (SNP) change the activity

Answer 2

change the rate of translocation
mis-folding of the protein
change the activity

Question 3

how does that influence the dose

Answer 3

increase the conc in the brain
reduce the dose

Question 4

guideline for the dose ?

Answer 4

not enough evidence

Question 5

phenytoin is mostly metabolised by

Answer 5

CYP2C9

Question 6

drugs which will be influenced by HLA-B 1502 mutation

Answer 6

phenytoin
carbamazepine
lamotrigine
phenobarbital

Question 7

substances which will increase the activity for CYP2C9

Answer 7

SJW

Question 8

alcohol will increase the serum conc for phenytoin Y/N

Answer 8

Y

Question 9

Calcium containing antacids will increase the phenytoin plasma conc Y/N

Answer 9

N (decrease)

Question 10

paroxetine is metabolised by

Answer 10

CYP2D6

Question 11

paroxetine shows non-linear PK due to

Answer 11

the metabolites inhibit the CYP2D6

Question 12

recommendation for CYP2D6 ultrarapid metaboliser

Answer 12

alternatives

Question 13

for poor metaboliser

Answer 13

alternatives

Question 14

sertraline only go through phase I metabolism Y/N

Answer 14

N

Question 15

CYP2C9 plays a role in sertraline metabolism Y / N

Answer 15

N (CYP2C19)

Question 16

routine test for CYP enzyme is NOT recommended Y/N

Answer 16

Y