Ach

Question 1

which enzyme convert DA to Norad

Answer 1

DA hydroxylase

Question 2

Negative feedback exists between which two substances

Answer 2

tyrosine hydroxylase and norad

Question 3

re-uptake of Norad

Answer 3

NET

Question 4

Norad is stored w in the vesicle

Answer 4

ATP and chromogranin A

Question 5

transport of Norad into the vesicle is carried by

Answer 5

VMAT

Question 6

two enzymes responsible for the breakdown of Norad

Answer 6

MAO and COMT

Question 7

autoinhibitory

Answer 7

alpha-2

Question 8

substances influence the re-uptake of Norad

Answer 8

cocaine / SNRI

Question 9

MOA of reserpine

Answer 9

inhibit the VMAT—Norad will be degraded by the enzyme—reduce the level of Norad

Question 10

MOA for amephetamine, ephedrine, and tyramine

Answer 10

taken up by the NET—displace the Norad in the vesicle—increase the level of Norad (More can escape)

Question 11

how antipsychotics cause hypotension

Answer 11

blockade of alpha-1 receptor

Question 12

why antipsychotics can bind to many other receptors (serotonin, adrenergic receptors)

Answer 12

all belongs to catecholamine–similarity in terms of the antagonist structure