nicotine

Question 1

major non-addictive metabolite

Answer 1

cotinine

Question 2

nicotine is metabolised by which enzyme

Answer 2

CYP2A6

Question 3

cause induction of

Answer 3

1A2 / 2B6

Question 4

smoking will increase the clearance for which antipsychotics

Answer 4

clozapine
olanzapine
haloperidol

Question 5

smoking will increase the clearance for which antidepressant

Answer 5

fluvoxamine
tricyclic antidepressant

Question 6

smoking will decrease the clearance for rivastigmine Y/N

Answer 6

N

Question 7

smoking will increase the clearance for tacrine Y/N

Answer 7

Y

Question 8

effect of nocotine

Answer 8

decreased appetite
increased cognition function
reduced anxiety

Question 9

typical withdrawl sx

Answer 9

insomnia
craving
irritablity

Question 10

5 R principle.

Answer 10

relevance
risk
reward
roadblock
repetition

Question 11

5A principle

Answer 11

ask
advice
assess
assist
arrange

Question 12

AAH principle

Answer 12

Ask
advice
help

Question 13

5 ways to assess the level of dependece

Answer 13

expired CO level
Fargerstrom
HSI
carboxyHb
urine, saliva or blood cotinine

Question 14

HSI focus on

Answer 14

how soon do u smoke the first cigarette after u waking up

how many cigarette perday ?

Question 15

forms of NRT

Answer 15

patch
lozenge
spray (mouth / nasal)
inhalation

Question 16

minimal duration of NRT

Answer 16

8 wks

Question 17

MOA for varenicline

Answer 17

partial agonist for alpha-4 / beta-2 receptor—reduce the pleasurable effect

Question 18

can be used for psychiatric patients
Y/N

Answer 18

N

Question 19

duration for varenicline

Answer 19

12 wks

Question 20

MOA for bupropion

Answer 20

receptor antagonist
DA / Norad re-uptake inhibitor