nicotine Flashcards
major non-addictive metabolite
cotinine
nicotine is metabolised by which enzyme
CYP2A6
cause induction of
1A2 / 2B6
smoking will increase the clearance for which antipsychotics
clozapine
olanzapine
haloperidol
smoking will increase the clearance for which antidepressant
fluvoxamine
tricyclic antidepressant
smoking will decrease the clearance for rivastigmine Y/N
N
smoking will increase the clearance for tacrine Y/N
Y
effect of nocotine
decreased appetite
increased cognition function
reduced anxiety
typical withdrawl sx
insomnia
craving
irritablity
5 R principle.
relevance
risk
reward
roadblock
repetition
5A principle
ask
advice
assess
assist
arrange
AAH principle
Ask
advice
help
5 ways to assess the level of dependece
expired CO level
Fargerstrom
HSI
carboxyHb
urine, saliva or blood cotinine
HSI focus on
how soon do u smoke the first cigarette after u waking up
how many cigarette perday ?
forms of NRT
patch
lozenge
spray (mouth / nasal)
inhalation
minimal duration of NRT
8 wks
MOA for varenicline
partial agonist for alpha-4 / beta-2 receptor—reduce the pleasurable effect
can be used for psychiatric patients
Y/N
N
duration for varenicline
12 wks
MOA for bupropion
receptor antagonist
DA / Norad re-uptake inhibitor
