Petechiae, Purpura, and Vasculitis - Schwarzenberger Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What is purpura?

A

Essentially “blood under the skin”

  • non-blanchable, pink to purple macules/patches or papules caused by extravasated RBC’s in skin or mucous membranes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 Main causes of purpura?

A
  • coagulation/clotting abnormalities
  • leaky or abnormal blood vessels
  • other causes, including trauma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

2 types of purpura? Which is associated with inflammation? Inflammatory purpura is a sign for what?

A
  • non-palpable/macular (NON inflammatory)
  • palable (inflammatory) = signs of vasculitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2 types of non-palpable purpura?

A

petechiae, ecchymosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What type of non-palpable purpura is this?

A

Petechiae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Petechiae features?

Size?

Location?

Painful or painless?

A
  • small <3 mm red or purple dots
  • usually on dependent areas of body
  • generally painless
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Who is most likely to have petechiae (2 types of pts)?

A

pt with hemophilia or with cancer receiving chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Petechiae is generally considered to be an abnormality in what?

A

platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Non-platelet related petechiae is usually due to what?

A

things that increase capillary fragility or allow them to leak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What was the dx of this type of petechiae?

A

Scurvy, due to vit C defiency

  • petechiae associated with hair follicles, hair is curled
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Non-scientific name for ecchymosis?

A

Bruise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Ecchymosis features?

Size?

Location on body?

Painful or painless?

A
  • Larger areas of purpura (>5mm)
  • can be anywhere on body
  • may/may not be painful, tender
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ecchymosis are usually due to what?

A

Coagulation defect (hyper or hypocoaguable)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Purpura is multifactorial.

A

Just know it.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Palpable purpura is a hallmark for ?

A

Leukocytoclastic vasculitis (this will be on the test. i guarantee it)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is this type of purpura Dr. S talked about? What immunoglobulin is it associated with?

A

HSP (Henoch-Schonlein purpura),

Associated with IgA (shown in clumps on IF)

17
Q

Unlike bland petechiae/ecchymosis, palpable purpura is assocaited with what?

A

Inflammation in blood vessels (aka vasculitis)

18
Q

Remember, where are blood vessels found?

A

Dermis/ Subq. not in epidermis

19
Q

Vasculitis classified based on?

A

Size of vessel involved (small, mixed small/medium, medium, large vessel vasculitis)

20
Q

Vasculitis is more predominantly seen in where geographically on body?

A

Dependent areas

  • Lower extremities (in ambulatory patients)
  • Ass cheeks in bed-ridden patients
21
Q

List features of small vessel vasculitis

A

palpable purpura

blisters, less commonly hives (like urticarial vasculitis)

22
Q

List features of medium vessel vasculitis

A
  • Nodules, purpura, livedo reticularis/racemosa
  • Ulcers, skin necrosis
23
Q

List features of large vessel vasculitis

A

Less likely to affect skin

24
Q

List diseases with small vessel vasculitis?

A

HSP, infections, Drug reactions, autoimmune diseases, malignancy associated vasculitis, Idiopathic

25
Q

Name some mixed (small/medium) vasculitis?

A

ANCA associated vasculitis (Churg-strauss, Microscopic polyangiitis, Wegner’s granulomatosis)

Cryoglobulinemic vasculitis

26
Q

Disease associated with medium vessel vasculitis?

A

Polyarteritis nodosa

27
Q

Diseases of large vessel vasculitis?

A

Giant cell arteritis, takayasu arteritis, Behcet’s

28
Q

Based on your understanding of how small, medium, and large vessel vasculitis present. Which type is this? Bonus points. Name that dx?

A

Churg-Strauss (small/medium vessel vasculitis)

  • not much palpable purpura, more nodules
29
Q

What do you call this pattern seen on skin? Associated with what disease/size of vessel involvement?

A

This is livedo reticularis, seen in polyarteritis nodosa (medium vessel vasculitis)

30
Q

Name this. A distinctive form of ecchymosis with a “net-like” pattern

Prognosis?

A

Retiform purpura

Worst kind of purpura to have.

31
Q

Retiform purpura results from what?

A

Vascular ischemia, usually due to an underlying thrombotic disorder

32
Q

This type of retiform purpura is known as? aka?

A

Purpura fulminans (DIC)

33
Q

Street drug associated with DIC?

A

Shitty cocaine. Key word: shitty

34
Q

Retiform pupura + fever. Most worrisome diagnosis?

A

Meningococcemia (wear gloves/mask)