Personalised Medicine Flashcards
What is Rubraca?
Poly-ADP ribose polymerase (PARP) inhibitor
How does Rubraca function?
Blocks mitosis
Who benefits most from Rubraca?
Those with a BRCA mutation
Give an example of cancer treated with Rubrace?
Ovarian
Patients with which genotypes benefit from Epclusa?
All
What two compounds make up Epclusa?
Sofosbuvir (blocks RNA polymerase)
Velapatasivir (NS5A replication complex inhibitor)
What is Atezoluzimab (TECENRIQ)?
Humanised antibody for non-small cell lung cancer
How does Atezoluzimab (TECENTRIQ) work?
Prevents interaction between PD-L1 (of a tomour cell) and B7-1 (of T cell) so that the T cell can kill the tumour cell.
Who does Atezoluzimab (TECENTRIQ) BENEFIT MOST?
Those with high PD-L1.
What is Exondys 51 (eteplirsen)?
Anti-sense oligonucleotide that exon 51 on the dystrophin gene so that it is also spliced out.
What is Glybera?
Replication deficient AAV1 vector with cytomegaloviral promotor expressing human LPL genes to teate lipoprotein lipase deficiency.
What are indels?
5-20 nt insertions/deletions made during non-homologous end joining, resulting in an inactive gene.
How long do homologous arms need to be in homologous end joining?
1000bp.
Of Z-fingers, TALENS and CRISPR/Cas9, which is the larget?
CRISPR/Cas9
In TALENS, which base do you need at the 5’ end of each targeted sequence?
Thymidine.
