Kidney Regeneration Flashcards
What percentage of podocyte loss characterises fibrosis?
20-40%
What percentage of podocyte loss characterises global sclerosis?
> 60%
List four possible uses of iPSC?
Disease modelling, toxicology screening, individual response to intervention, cell replacement therapy.
What is the potency of mesenchymal stem cells?
Multi-potent
How do mesenchymal stem cells reduce inflammation?
Interfere with dendritic cells and T cells, arrest B cell maturation and . proliferation, alter macrophage phenotype towards repair-type.
Why can mesenchymal stem cells be used for molecule delivery?
Mesenchymal stem cells have many exosomes. The cells or the exosomes can be used for delivery.