Antibodies Flashcards

1
Q

What portion of current therapeutics is made up by antibodies?

A

1/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the possible mechanisms of antibody action?

A

Ligand blockade, receptor blockade, receptor downregulation, depletion, signal induction.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How can antibodies use depletion?

A

Activate MAC complex, phagocytosis, lysis and pore formation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Once hybridomas are produced, how can they be selected for?

A

Block the de novo synthesis of nucleotides but provide precursors for the salvage pathway. Myeloma cells cannot use the salvage pathway, but hydridomas can.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What mechanism do antibodies use to target TNF?

A

Ligand blockade.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What kind of antibody is Rituximab?

A

Chimeric anti-human CD20 antibody.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does Rituximab function?

A

Bind to CD20 and activate complement pathways, NK cells and macrophages to kill B cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What kind of antibody is Adalimumab (humira)?

A

Fully human anti-TNF monoclonal antibody produced using guided selection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How were plants altered to produced Zmapp (ebola antibody)

A

Lack specific plant N-glycans and contain mammalian enzymes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly